Document Detail

Maternal Phenylketonuria International Collaborative Study revisited: evaluation of maternal nutritional risk factors besides phenylalanine for fetal congenital heart defects.
MedLine Citation:
PMID:  23784316     Owner:  NLM     Status:  Publisher    
Maternal phenylketonuria (MPKU) is known to affect fetal outcome, often being associated with microcephaly and congenital heart defects (CHD) if the maternal diet is not appropriately managed. We hypothesized that other nutrients aside from phenylalanine (Phe) may have significant effects on fetal outcome in MPKU pregnancies. The 416 pregnancies that resulted in live births reported in the Maternal PKU Collaborative Study (MPKUCS) were grouped according to whether or not the offspring were diagnosed with CHD. The groups were compared on first-trimester values of maternal data, including weight gain, plasma amino acids, protein and Phe intake, and red blood cell (RBC) folate. Patients were also grouped by first-trimester average blood Phe (≤910 μmol/L and >910 μmol/L) and then divided by total natural protein and medical food intake. The CHD group of 28 offspring had significantly higher blood Phe and lower proline, valine, methionine, isoleucine, leucine, lysine, arginine, and RBC folate. A significantly higher risk for CHD was found in the groups with lower natural protein and medical food intake, regardless of blood Phe levels. Insufficient natural protein and medical food product intake appears to be a risk factor for CHD independent of first-trimester plasma Phe levels. Low RBC folate and plasma methionine levels in the CHD group may suggest involvement of global DNA hypomethylation.
Shoji Yano; Kathryn Moseley; Teodoro Bottiglieri; Erland Arning; Colleen Azen
Related Documents :
10890926 - Very low birthweight infant's placenta and its relation to pregnancy and fetal characte...
10838316 - The effects of in vitro fertilization on subsequent pregnancy outcome.
19761606 - Pessaries in multiple pregnancy as a prevention of preterm birth: the protwin trial.
10796206 - Antibiotics for asymptomatic bacteriuria in pregnancy.
10796236 - Operative versus conservative management for 'fetal distress' in labour.
23972746 - The association between epidural labor analgesia and maternal fever.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-6-20
Journal Detail:
Title:  Journal of inherited metabolic disease     Volume:  -     ISSN:  1573-2665     ISO Abbreviation:  J. Inherit. Metab. Dis.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-6-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7910918     Medline TA:  J Inherit Metab Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Genetics Division, Department of Pediatrics, LAC + USC Medical Center, Keck School of Medicine, University of Southern California, General Laboratory Building Room 1G-24, 1801 Marengo Street, Los Angeles, CA, 90033, USA,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Three-dimensional deep sub-diffraction optical beam lithography with 9?nm feature size.
Next Document:  Fracture of the talar neck associated with a compression fracture of the calcaneocuboid joint in a 5...