Document Detail


Maternal periodontitis treatment and child neurodevelopment at 24 to 28 months of age.
MedLine Citation:
PMID:  21482606     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Some maternal infections are associated with impaired infant cognitive and motor performance. Periodontitis results in frequent bacteremia and elevated serum inflammatory mediators.
OBJECTIVE: The purpose of this study was to determine if periodontitis treatment in pregnant women affects infant cognitive, motor, or language development.
METHODS: Children born to women who had participated in a previous trial were assessed between 24 and 28 months of age by using the Bayley Scales of Infant and Toddler Development (Third Edition) and the Preschool Language Scale (Fourth Edition). Information about the pregnancy, neonatal period, and home environment was obtained through chart abstractions, laboratory test results, and questionnaires. We compared infants born to women treated for periodontitis before 21 weeks' gestation (treatment group) or after delivery (controls). In unadjusted and adjusted analyses, associations between change in maternal periodontal condition during pregnancy and neurodevelopment scores were tested by using Student's t tests and linear regression.
RESULTS: A total of 411 of 791 eligible mother/caregiver-child pairs participated. Thirty-seven participating children (9.0%) were born at <37 weeks' gestation. Infants in the treatment and control groups did not differ significantly for adjusted mean cognitive (90.7 vs 91.4), motor (96.8 vs 97.2), or language (92.2 vs 92.1) scores (all P > .5). Results were similar in adjusted analyses. Children of women who experienced greater improvements in periodontal health had significantly higher motor and cognitive scores (P = .01 and .02, respectively), although the effect was small (∼1-point increase for each SD increase in the periodontal measure).
CONCLUSION: Nonsurgical periodontitis treatment in pregnant women was not associated with cognitive, motor, or language development in these study children.
Authors:
Bryan S Michalowicz; James S Hodges; Richard C Lussky; Henrietta Bada; Twila Rawson; L Susan Buttross; Claudia Chiriboga; Anthony J Diangelis; M John Novak; William Buchanan; Dennis A Mitchell; Panos N Papapanou
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2011-04-11
Journal Detail:
Title:  Pediatrics     Volume:  127     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-02     Completed Date:  2011-07-11     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e1212-20     Citation Subset:  AIM; IM    
Affiliation:
Department of Developmental and Surgical Sciences, School of Dentistry, University of Minnesota, 17-116 Moos Tower, 515 Delaware St SE, Minneapolis, MN 55455, USA. micha002@umn.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Child Development / physiology
Child, Preschool
Cognition Disorders / epidemiology*,  etiology
Developmental Disabilities / epidemiology*,  etiology,  physiopathology
Female
Gestational Age
Humans
Incidence
Language Development
Linear Models
Male
Maternal Welfare
Motor Skills Disorders / epidemiology*,  etiology,  physiopathology
Multivariate Analysis
Oral Health
Periodontitis / complications,  diagnosis*,  therapy*
Pregnancy
Pregnancy Complications, Infectious / diagnosis*
Risk Assessment
Severity of Illness Index
Grant Support
ID/Acronym/Agency:
U01 DE014338/DE/NIDCR NIH HHS
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