Document Detail

Maternal Periodontal Disease is Associated with Oxidative Stress during Pregnancy.
MedLine Citation:
PMID:  21082538     Owner:  NLM     Status:  Publisher    
We sought to determine if maternal periodontal disease is associated with oxidative stress as measured by serum 8-isoprostane. A secondary analysis was conducted using prospective data from the Oral Conditions and Pregnancy Study. Healthy women enrolled at < 26 weeks' gestational age underwent oral examination and serum sampling. Maternal periodontal disease status was categorized as healthy, mild, or moderate to severe by clinical criteria. Maternal serum was analyzed for 8-isoprostane using ultrasensitive enzyme-linked immunosorbent assay. Elevated 8-isoprostane level was defined as ≥ 75th percentile. Maternal factors associated with elevated 8-isoprostane were determined using chi-square or T test. Multivariable logistic regression was used to assess association between elevated 8-isoprostane and maternal factors. Seven hundred ninety-one women had complete data. Median (interquartile) 8-isoprostane serum level was 1806 (16 to 81,870) pg/dL. Using bivariate analysis, maternal age, race, marital status, utilization of public assistance, and mild or moderate to severe periodontal disease were associated with elevated serum 8-isoprostane. Using logistic regression, moderate to severe periodontal disease (adjusted odds ratio 2.9, 95% confidence interval: 1.7 to 5.0) remained significantly associated with an elevated serum 8-isoprostane level. Maternal periodontal disease is associated with oxidative stress during pregnancy. Further study is needed to determine the role of maternal oxidative stress in periodontal disease-associated adverse pregnancy outcomes.
M Ashley Hickman; Kim A Boggess; Kevin L Moss; James D Beck; Steven Offenbacher
Related Documents :
23886298 - Efficacy and safety of metformin during pregnancy in women with gestational diabetes me...
18840538 - Chemical characterization of milk oligosaccharides of a spotted hyena (crocuta crocuta).
24625708 - Fetal spasms after the administration of electroconvulsive therapy in pregnancy: our ex...
24269788 - Discussion: 'sleep-disordered breathing and adverse pregnancy outcomes' by pamidi et al.
22510618 - Ectopic pregnancy: history, incidence, epidemiology, and risk factors.
7438968 - Modulation of monooxygenase activities by hematin and 7,8-benzoflavone in fetal tissues...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-11-16
Journal Detail:
Title:  American journal of perinatology     Volume:  -     ISSN:  1098-8785     ISO Abbreviation:  Am J Perinatol     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© Thieme Medical Publishers.
University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Exchange of Peripherally Inserted Central Catheters is Associated with an Increased Risk for Bloodst...
Next Document:  Type and Timing of Ventilation in the First Postnatal Week is Associated with Bronchopulmonary Dyspl...