| Maternal Periodontal Disease is Associated with Oxidative Stress during Pregnancy. | |
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MedLine Citation:
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PMID: 21082538 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We sought to determine if maternal periodontal disease is associated with oxidative stress as measured by serum 8-isoprostane. A secondary analysis was conducted using prospective data from the Oral Conditions and Pregnancy Study. Healthy women enrolled at < 26 weeks' gestational age underwent oral examination and serum sampling. Maternal periodontal disease status was categorized as healthy, mild, or moderate to severe by clinical criteria. Maternal serum was analyzed for 8-isoprostane using ultrasensitive enzyme-linked immunosorbent assay. Elevated 8-isoprostane level was defined as ≥ 75th percentile. Maternal factors associated with elevated 8-isoprostane were determined using chi-square or T test. Multivariable logistic regression was used to assess association between elevated 8-isoprostane and maternal factors. Seven hundred ninety-one women had complete data. Median (interquartile) 8-isoprostane serum level was 1806 (16 to 81,870) pg/dL. Using bivariate analysis, maternal age, race, marital status, utilization of public assistance, and mild or moderate to severe periodontal disease were associated with elevated serum 8-isoprostane. Using logistic regression, moderate to severe periodontal disease (adjusted odds ratio 2.9, 95% confidence interval: 1.7 to 5.0) remained significantly associated with an elevated serum 8-isoprostane level. Maternal periodontal disease is associated with oxidative stress during pregnancy. Further study is needed to determine the role of maternal oxidative stress in periodontal disease-associated adverse pregnancy outcomes. |
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Authors:
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M Ashley Hickman; Kim A Boggess; Kevin L Moss; James D Beck; Steven Offenbacher |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-11-16 |
Journal Detail:
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Title: American journal of perinatology Volume: - ISSN: 1098-8785 ISO Abbreviation: Am J Perinatol Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8405212 Medline TA: Am J Perinatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© Thieme Medical Publishers. |
Affiliation:
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University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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