Document Detail

Maternal obesity and its relationship with spontaneous and oxytocin-induced contractility of human myometrium in vitro.
MedLine Citation:
PMID:  19828431     Owner:  NLM     Status:  MEDLINE    
Maternal obesity is associated with increased rates of labor induction, dysfunctional labor requiring intrapartum cesarean delivery, and postpartum hemorrhage, implying that maternal obesity has an inhibitory effect on myometrial function and its ability to respond to oxytocin. This study aimed to use an in vitro model to investigate the relationship between maternal body mass index (BMI) and the ability of myometrium to contract spontaneously and in response to oxytocin. Linear mixed effects regression modeling was applied to contractile data from 609 strips from 85 women. No correlation was found between maternal BMI and any indices of spontaneous myometrial activity. A single addition of oxytocin increased contractility, however, this was not related to maternal BMI. Similarly, oxytocin concentration-response curves were unrelated to BMI. Overall, the results from this in vitro study suggest that the observed implications of obesity on parturition in vivo cannot be explained by a direct effect on myometrial contractile mechanisms per se.
Claire A Higgins; William Martin; Laurie Anderson; Andrew M Blanks; Jane E Norman; A McConnachie; S M Nelson
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-10-13
Journal Detail:
Title:  Reproductive sciences (Thousand Oaks, Calif.)     Volume:  17     ISSN:  1933-7205     ISO Abbreviation:  Reprod Sci     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-04     Completed Date:  2010-04-22     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  101291249     Medline TA:  Reprod Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  177-85     Citation Subset:  IM    
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MeSH Terms
Body Mass Index
Dose-Response Relationship, Drug
Linear Models
Myometrium / cytology,  physiology*
Obesity / physiopathology*
Oxytocin / pharmacology*
Pregnancy Complications / physiopathology*
Uterine Contraction / drug effects*,  physiology*
Young Adult
Grant Support
CZB/4/408//Chief Scientist Office; //Chief Scientist Office
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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