| Maternal obesity and vitamin D sufficiency are associated with cord blood vitamin D insufficiency. | |
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MedLine Citation:
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PMID: 23144468 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: An inverse relationship between total serum 25-hydroxyvitamin D (25-OH D) and increased adiposity has been established in children, adolescents, and adults. However, the relationship between neonatal adiposity and vitamin D status has not been reported. Both maternal obesity and vitamin D deficiency in pregnancy are common and are associated with adverse pregnancy outcomes. OBJECTIVE: The aim of the study was to determine the relationship between vitamin D levels in mothers and newborns, as influenced by maternal obesity, and evaluate these associations with neonatal adiposity. DESIGN, SETTING, AND PATIENTS: Sixty-one maternal-neonatal pairs participated in this cross-sectional study at an academic medical center. Mothers had a prepregnancy body mass index that was normal or obese. OUTCOME MEASURES: Maternal and cord blood sera were assayed for 25-OH D, and neonatal body composition was measured by air displacement plethysmography. RESULTS: Mothers had similar and sufficient levels of 25-OH D when measured at 36-38 wk gestation, irrespective of body mass index category (normal weight, 46.05, vs. obese, 49.84 ng/ml; P = not significant). However, cord blood 25-OH D was higher in neonates of normal-weight mothers compared to neonates of obese mothers (27.45 vs. 20.81 ng/ml; P = 0.02). The variance in cord blood 25-OH D was explained by four factors: maternal 25-OH D level, the presence of maternal obesity, maternal age, and neonatal adiposity (r(2) = 0.66). CONCLUSION: Obese women transfer less 25-OH D to offspring than normal-weight women, despite similar serum levels. Cord blood 25-OH D levels directly correlate to neonatal percentage body fat. These novel findings underscore the evolving relationships between maternal obesity, vitamin D nutritional status, and adiposity in the neonatal period that may influence subsequent childhood and adulthood vitamin D-dependent processes. |
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Authors:
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Jami L Josefson; Joseph Feinglass; Alfred W Rademaker; Boyd E Metzger; Dinah M Zeiss; Heather E Price; Craig B Langman |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-11-08 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 98 ISSN: 1945-7197 ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-01-07 Completed Date: 2013-03-07 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 114-9 Citation Subset: AIM; IM |
Affiliation:
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Division of Pediatric Endocrinology, Ann and Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611-2605, USA. J-Josefson@northwestern.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Body Mass Index Case-Control Studies Female Fetal Blood / chemistry*, metabolism Humans Infant, Newborn Infant, Newborn, Diseases / blood, epidemiology, etiology Obesity / blood, complications*, epidemiology Pregnancy Pregnancy Complications / blood*, epidemiology Prenatal Exposure Delayed Effects / blood, epidemiology Risk Factors Vitamin D / analysis, blood*, metabolism Vitamin D Deficiency / blood, congenital*, epidemiology, etiology* |
| Grant Support | |
ID/Acronym/Agency:
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AG 032227/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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1406-16-2/Vitamin D |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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