Document Detail

Maternal obesity and vitamin D sufficiency are associated with cord blood vitamin D insufficiency.
MedLine Citation:
PMID:  23144468     Owner:  NLM     Status:  MEDLINE    
CONTEXT: An inverse relationship between total serum 25-hydroxyvitamin D (25-OH D) and increased adiposity has been established in children, adolescents, and adults. However, the relationship between neonatal adiposity and vitamin D status has not been reported. Both maternal obesity and vitamin D deficiency in pregnancy are common and are associated with adverse pregnancy outcomes.
OBJECTIVE: The aim of the study was to determine the relationship between vitamin D levels in mothers and newborns, as influenced by maternal obesity, and evaluate these associations with neonatal adiposity.
DESIGN, SETTING, AND PATIENTS: Sixty-one maternal-neonatal pairs participated in this cross-sectional study at an academic medical center. Mothers had a prepregnancy body mass index that was normal or obese.
OUTCOME MEASURES: Maternal and cord blood sera were assayed for 25-OH D, and neonatal body composition was measured by air displacement plethysmography.
RESULTS: Mothers had similar and sufficient levels of 25-OH D when measured at 36-38 wk gestation, irrespective of body mass index category (normal weight, 46.05, vs. obese, 49.84 ng/ml; P = not significant). However, cord blood 25-OH D was higher in neonates of normal-weight mothers compared to neonates of obese mothers (27.45 vs. 20.81 ng/ml; P = 0.02). The variance in cord blood 25-OH D was explained by four factors: maternal 25-OH D level, the presence of maternal obesity, maternal age, and neonatal adiposity (r(2) = 0.66).
CONCLUSION: Obese women transfer less 25-OH D to offspring than normal-weight women, despite similar serum levels. Cord blood 25-OH D levels directly correlate to neonatal percentage body fat. These novel findings underscore the evolving relationships between maternal obesity, vitamin D nutritional status, and adiposity in the neonatal period that may influence subsequent childhood and adulthood vitamin D-dependent processes.
Jami L Josefson; Joseph Feinglass; Alfred W Rademaker; Boyd E Metzger; Dinah M Zeiss; Heather E Price; Craig B Langman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-11-08
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  98     ISSN:  1945-7197     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-07     Completed Date:  2013-03-07     Revised Date:  2014-06-02    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  114-9     Citation Subset:  AIM; IM    
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MeSH Terms
Body Mass Index
Case-Control Studies
Fetal Blood / chemistry*,  metabolism
Infant, Newborn
Infant, Newborn, Diseases / blood,  epidemiology,  etiology
Obesity / blood,  complications*,  epidemiology
Pregnancy Complications / blood*,  epidemiology
Prenatal Exposure Delayed Effects / blood,  epidemiology
Risk Factors
Vitamin D / analysis,  blood*,  metabolism
Vitamin D Deficiency / blood,  congenital*,  epidemiology,  etiology*
Grant Support
Reg. No./Substance:
1406-16-2/Vitamin D

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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