| Maternal Obesity Is Associated with the Formation of Small Dense LDL and Hypoadiponectinemia in the Third Trimester. | |
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MedLine Citation:
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PMID: 23337718 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Context:Maternal obesity is associated with high plasma triglyceride, poor vascular function, and an increased risk for pregnancy complications. In normal-weight pregnant women, higher triglyceride is associated with increased small, dense low-density lipoprotein (LDL).Hypothesis:In obese pregnancy, increased plasma triglyceride concentrations result in triglyceride enrichment of very low-density lipoprotein-1 particles and formation of small dense LDL via lipoprotein lipase.Design:Women (n = 55) of body mass index of 18-46 kg/m(2) were sampled longitudinally at 12, 26, and 35 weeks' gestation and 4 months postnatally.Setting:Women were recruited at hospital antenatal appointments, and study visits were in a clinical research suite.Outcome Measures:Plasma concentrations of lipids, triglyceride-rich lipoproteins, lipoprotein lipase mass, estradiol, steroid hormone binding globulin, insulin, glucose, leptin, and adiponectin were determined.Results:Obese women commenced pregnancy with higher plasma triglyceride, reached the same maximum, and then returned to higher postnatal levels than normal-weight women. Estradiol response to pregnancy (trimester 1-3 incremental area under the curve) was positively associated with plasma triglyceride response (r(2) adjusted 25%, P < .001). In the third trimester, the proportion of small, dense LDL was 2-fold higher in obese women than normal-weight women [mean (SD) 40.7 (18.8) vs 21.9 (10.9)%, P = .014], and 35% of obese, 14% of overweight, and none of the normal-weight women displayed an atherogenic LDL subfraction phenotype. The small, dense LDL mass response to pregnancy was inversely associated with adiponectin response (17%, P = .013).Conclusions:Maternal obesity is associated with an atherogenic LDL subfraction phenotype and may provide a mechanistic link to poor vascular function and adverse pregnancy outcome. |
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Authors:
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Barbara J Meyer; Frances M Stewart; Elizabeth A Brown; Josephine Cooney; Solveig Nilsson; Gunilla Olivecrona; Jane E Ramsay; Bruce A Griffin; Muriel J Caslake; Dilys J Freeman |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-21 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: - ISSN: 1945-7197 ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Metabolic Research Centre (B.J.M.), School of Health Sciences, University of Wollongong, Wollongong, New South Wales 2500, Australia; School of Medicine (F.M.S., J.E.R.) and Institute of Cardiovascular and Medical Sciences (E.A.B., J.C., M.J.C., D.J.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; Department of Medical Biosciences (S.N., G.O.), Umeå University, SE-901 87 Umeå, Sweden; and Department of Nutritional Sciences (B.A.G.), Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, United Kingdom. |
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