Document Detail

Maternal obesity is associated with the formation of small dense LDL and hypoadiponectinemia in the third trimester.
MedLine Citation:
PMID:  23337718     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Maternal obesity is associated with high plasma triglyceride, poor vascular function, and an increased risk for pregnancy complications. In normal-weight pregnant women, higher triglyceride is associated with increased small, dense low-density lipoprotein (LDL).
HYPOTHESIS: In obese pregnancy, increased plasma triglyceride concentrations result in triglyceride enrichment of very low-density lipoprotein-1 particles and formation of small dense LDL via lipoprotein lipase.
DESIGN: Women (n = 55) of body mass index of 18-46 kg/m(2) were sampled longitudinally at 12, 26, and 35 weeks' gestation and 4 months postnatally.
SETTING: Women were recruited at hospital antenatal appointments, and study visits were in a clinical research suite.
OUTCOME MEASURES: Plasma concentrations of lipids, triglyceride-rich lipoproteins, lipoprotein lipase mass, estradiol, steroid hormone binding globulin, insulin, glucose, leptin, and adiponectin were determined.
RESULTS: Obese women commenced pregnancy with higher plasma triglyceride, reached the same maximum, and then returned to higher postnatal levels than normal-weight women. Estradiol response to pregnancy (trimester 1-3 incremental area under the curve) was positively associated with plasma triglyceride response (r(2) adjusted 25%, P < .001). In the third trimester, the proportion of small, dense LDL was 2-fold higher in obese women than normal-weight women [mean (SD) 40.7 (18.8) vs 21.9 (10.9)%, P = .014], and 35% of obese, 14% of overweight, and none of the normal-weight women displayed an atherogenic LDL subfraction phenotype. The small, dense LDL mass response to pregnancy was inversely associated with adiponectin response (17%, P = .013).
CONCLUSIONS: Maternal obesity is associated with an atherogenic LDL subfraction phenotype and may provide a mechanistic link to poor vascular function and adverse pregnancy outcome.
Barbara J Meyer; Frances M Stewart; Elizabeth A Brown; Josephine Cooney; Solveig Nilsson; Gunilla Olivecrona; Jane E Ramsay; Bruce A Griffin; Muriel J Caslake; Dilys J Freeman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-21
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  98     ISSN:  1945-7197     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-07     Completed Date:  2013-04-10     Revised Date:  2014-06-17    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  643-52     Citation Subset:  AIM; IM    
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MeSH Terms
Adiponectin / blood,  deficiency
Cholesterol, LDL / blood*
Lipoproteins, LDL / blood*
Metabolism, Inborn Errors / blood,  complications*
Obesity / blood,  complications*
Pregnancy Complications / blood*
Pregnancy Trimester, Third / blood*
Triglycerides / blood
Grant Support
PG/02/167/14801//British Heart Foundation; PG/02/167/14801//British Heart Foundation
Reg. No./Substance:
0/Adiponectin; 0/Cholesterol, LDL; 0/Lipoproteins, LDL; 0/Triglycerides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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