Document Detail


Maternal nutritional status in early pregnancy is associated with body water and plasma volume changes in a pregnancy cohort in rural Bangladesh.
MedLine Citation:
PMID:  22535759     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Plasma volume expansion has been associated with fetal growth. Our objective was to examine the associations between maternal nutritional status in early pregnancy and extracellular water (ECW), total body water (TBW), and percentage plasma volume change across pregnancy. In a subsample of 377 pregnant women participating in a cluster-randomized trial of micronutrient supplementation, hemoglobin, hematocrit, and multi-frequency bioelectrical impedance were measured at ~10, 20, and 32 wk of gestation. In early pregnancy, women were short (mean ± SD, 148.9 ± 5.3 cm) and thin (19.5 ± 2.5 kg/m(2)). In mixed-effects multiple regression models, a 1-unit higher BMI at ~10 wk was associated with higher ECW and TBW (0.27 and 0.66 kg per kg/m(2), respectively; P < 0.01) at ~10, ~20, and ~32 wk. Height was also positively associated with ECW and TBW at each time point. Early pregnancy BMI was negatively associated with gains in ECW and TBW (-0.06 and -0.14 kg per kg/m(2), respectively; P < 0.01) from 10 to 20 wk, but not with 20- to 32-wk gains after accounting for weight gain. BMI was positively associated with percentage changes in plasma volume from 20 to 32 wk (0.57% per kg/m(2); P < 0.05). Height was not associated with changes in body water or plasma volume. Women with low BMI and height in early pregnancy have lower ECW and TBW in early, mid, and late pregnancy and lower late pregnancy plasma volume expansion, potentially increasing risk of fetal growth restriction.
Authors:
Alison D Gernand; Parul Christian; Kerry J Schulze; Saijuddin Shaikh; Alain B Labrique; Abu Ahmed Shamim; Keith P West
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-04-25
Journal Detail:
Title:  The Journal of nutrition     Volume:  142     ISSN:  1541-6100     ISO Abbreviation:  J. Nutr.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-21     Completed Date:  2012-07-25     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1109-15     Citation Subset:  IM    
Affiliation:
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Bangladesh
Body Water / physiology*
Cohort Studies
Dietary Supplements
Double-Blind Method
Extracellular Fluid
Female
Humans
Maternal Nutritional Physiological Phenomena*
Micronutrients / administration & dosage*
Nutritional Status / physiology*
Plasma Volume / physiology*
Pregnancy
Rural Population
Young Adult
Grant Support
ID/Acronym/Agency:
T32HD046405/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Micronutrients
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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