Document Detail

Maternal nicotine exposure and fetal programming of vascular oxidative stress in adult offspring.
MedLine Citation:
PMID:  21585345     Owner:  NLM     Status:  MEDLINE    
Despite the well-known harmful effects, many women continue to smoke throughout pregnancy. Consequently, nicotine replacement therapy (NRT) - which has been developed as a pharmacotherapy for smoking cessation - has been used as an alternative to smoking during pregnancy. However, like cigarette smoking, NRT results in biologically significant levels of nicotine crossing the placenta, leading to both fetal and neonatal exposure to nicotine, and yet, NRT safety during pregnancy has not been extensively evaluated. There is now evidence from studies in rats that maternal nicotine exposure throughout gestation results in fetal programming of vascular oxidative stress in the offspring during adulthood. This phenomenon involves vascular dysfunction mediated by reactive oxygen species in association with decreased superoxide dismutase activity and increased Nox2-NADPH oxidase expression in the vascular wall. If this phenomenon also occurs in humans, either smoking or NRT use during pregnancy may represent a novel risk factor for the unborn that results in accelerated cardiovascular disease in their adulthood.
Rebecca Lim; Christopher G Sobey
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  British journal of pharmacology     Volume:  164     ISSN:  1476-5381     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-12     Completed Date:  2012-02-13     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1397-9     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. British Journal of Pharmacology © 2011 The British Pharmacological Society.
The Ritchie Centre, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia.
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MeSH Terms
Hypertension / chemically induced*
Nicotine / adverse effects*
Oxidative Stress / drug effects*
Prenatal Exposure Delayed Effects / chemically induced*
Reg. No./Substance:
Comment On:
Br J Pharmacol. 2011 Nov;164(5):1400-9   [PMID:  21777225 ]

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