Document Detail

Maternal multiple micronutrient supplementation has limited impact on micronutrient status of Bangladeshi infants compared with standard iron and folic acid supplementation.
MedLine Citation:
PMID:  20053938     Owner:  NLM     Status:  MEDLINE    
Knowledge about the impact of maternal food and micronutrient supplementation on infant micronutrient status is limited. We examined the effect of maternal food and micronutrient supplementation on infant micronutrient status in the Maternal and Infant Nutrition Interventions in Matlab Trial. Pregnant women (n = 4436) were randomized to Early or Usual promotion of enrollment in a food supplementation program. In addition, they were randomly allocated to 1 of the following 3 types of daily micronutrient supplements provided from wk 14 of gestation to 3 mo postpartum: 1) folic acid and 30 mg iron (Fe30Fol); 2) folic acid and 60 mg iron; or 3) a multiple micronutrient including folic acid and 30 mg iron (MMS). At 6 mo, infant blood samples (n = 1066) were collected and analyzed for hemoglobin and plasma ferritin, zinc, retinol, vitamin B-12, and folate. The vitamin B-12 concentration differed between the micronutrient supplementation groups (P = 0.049). The prevalence of vitamin B-12 deficiency was lower in the MMS group (26.1%) than in the Fe30Fol group (36.5%) (P = 0.003). The prevalence of zinc deficiency was lower in the Usual food supplementation group (54.1%) than in the Early group (60.2%) (P = 0.046). There were no other differential effects according to food or micronutrient supplementation groups. We conclude that maternal multiple micronutrient supplementation may have a beneficial effect on vitamin B-12 status in infancy.
Hanna Eneroth; Shams El Arifeen; Lars-Ake Persson; Bo L?nnerdal; Mohammad Bakhtiar Hossain; Charles B Stephensen; Eva-Charlotte Ekstr?m
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-01-06
Journal Detail:
Title:  The Journal of nutrition     Volume:  140     ISSN:  1541-6100     ISO Abbreviation:  J. Nutr.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-22     Completed Date:  2010-03-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  618-24     Citation Subset:  IM    
International Maternal and Child Health, Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
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MeSH Terms
Dietary Supplements*
Drug Administration Schedule
Drug Therapy, Combination
Folic Acid / administration & dosage*,  pharmacology
Infant Nutritional Physiological Phenomena
Iron / administration & dosage*,  pharmacology
Maternal Nutritional Physiological Phenomena
Micronutrients / administration & dosage*,  pharmacology
Vitamin B 12 / blood
Vitamins / administration & dosage,  pharmacology
Young Adult
Grant Support
//Medical Research Council
Reg. No./Substance:
0/Micronutrients; 0/Vitamins; 59-30-3/Folic Acid; 68-19-9/Vitamin B 12; 7439-89-6/Iron

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