| Maternal MTHFR 677C>T genotype and dietary intake of folate and vitamin B(12): their impact on child neurodevelopment. | |
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MedLine Citation:
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PMID: 19178787 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Using the Bayley test, the mental and psychomotor development in a cohort of 253 children were evaluated. Maternal dietary intake of vitamin B(12) and folate was assessed from a semiquantitative questionnaire administered during the first trimester of pregnancy. Maternal genotypes of MTHFR (677C>T and 1298A>C), were ascertained by PCR-RFLP. The 677T and 1298C variant alleles were present in 59% and 10% of participants, respectively. A dietary deficiency of vitamin B(12) was negatively associated with mental development (beta = -1.6; 95% CI = -2.8 to -0.3). In contrast, dietary intake of folate (< 400 mg/day) reduced the mental development index only among children of mothers who were carriers of the TT genotype (beta = -1.8; 95% CI = -3.6 to -0.04; P for interaction = 0.07). Vitamin B(12) and folate supplementation during pregnancy could have a favorable impact on the mental development of children during their first year of life, mainly in populations that are genetically susceptible. |
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Authors:
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Constanza del Río Garcia; Luisa Torres-Sánchez; Jia Chen; Lourdes Schnaas; Carmen Hernández; Erika Osorio; Marcia Galván Portillo; Lizbeth López-Carrillo |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nutritional neuroscience Volume: 12 ISSN: 1476-8305 ISO Abbreviation: Nutr Neurosci Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-30 Completed Date: 2009-05-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892202 Medline TA: Nutr Neurosci Country: England |
Other Details:
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Languages: eng Pagination: 13-20 Citation Subset: IM |
Affiliation:
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Instituto Nacional de Salud Pública, Morelos, Mexico. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Brain / growth & development* Child Development / physiology Cohort Studies Diet* Environment Female Folic Acid / administration & dosage* Folic Acid Deficiency / complications Genotype Humans Infant Methylenetetrahydrofolate Reductase (NADPH2) / genetics* Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Pregnancy Pregnancy Complications Prenatal Exposure Delayed Effects* Psychomotor Disorders / epidemiology, etiology Vitamin B 12 / administration & dosage* Vitamin B 12 Deficiency / complications |
| Grant Support | |
ID/Acronym/Agency:
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D43 TW00640/TW/FIC NIH HHS |
| Chemical | |
Reg. No./Substance:
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59-30-3/Folic Acid; 68-19-9/Vitamin B 12; EC 1.5.1.20/Methylenetetrahydrofolate Reductase (NADPH2) |
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