Document Detail


The Maternal Lifestyle Study (MLS): effects of prenatal cocaine and/or opiate exposure on auditory brain response at one month.
MedLine Citation:
PMID:  12640376     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To study absolute and interpeak latencies of the auditory brain response in infants exposed to cocaine and/or opiates in utero.Study design The sample included 477 exposed and 554 comparison infants matched for race, sex, and gestational age. Mothers were recruited at 4 urban university-based centers; most were black, receiving public assistance, and had received adequate prenatal care. Exposure was determined by meconium assay and self-report with alcohol, marijuana, and tobacco present in both groups. At 1 month, infants were tested by masked examiners with the auditory brain response. RESULTS: Analyses were conducted for exposed and comparison groups and for level of prenatal cocaine exposure with adjustment for covariates (alcohol, marijuana, tobacco, gestational age at birth, social class, and site). Heavy prenatal cocaine exposure (>/=3 days per week, first trimester) led to an increase in the I-III, I-V, and III-V interpeak latencies and to a shorter latency to peak I. Infants with prenatal opiate exposure showed a longer latency to peak V and a longer III-V interpeak latency. CONCLUSIONS: Prenatal cocaine and/or opiate exposure affects neural transmission. Detection of these effects requires a large sample with control for gestational age, other drugs, and level of cocaine use.
Authors:
Barry M Lester; Linda Lagasse; Ronald Seifer; Edward Z Tronick; Charles R Bauer; Seetha Shankaran; Henrietta S Bada; Linda L Wright; Vincent L Smeriglio; Jing Liu; Loretta P Finnegan; Penelope L Maza
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  142     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-17     Completed Date:  2003-04-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  279-85     Citation Subset:  AIM; IM    
Affiliation:
Brown Medical School, the Infant Development Center, Women and Infant's Hospital, and Bradley Hospital, Providence, Rhode Island 02905-2499, USA.
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MeSH Terms
Descriptor/Qualifier:
Alcohol Drinking
Cocaine / adverse effects*
Cocaine-Related Disorders / complications
Evoked Potentials, Auditory, Brain Stem / drug effects*
Female
Humans
Infant
Longitudinal Studies
Narcotics / adverse effects*
Opioid-Related Disorders / complications
Pregnancy
Pregnancy Complications
Prenatal Exposure Delayed Effects*
Smoking
Socioeconomic Factors
Urban Health
Grant Support
ID/Acronym/Agency:
N01-HD-2-3159/HD/NICHD NIH HHS; U10 HD 21385/HD/NICHD NIH HHS; U10 HD 21397/HD/NICHD NIH HHS; U10 HD 27856/HD/NICHD NIH HHS; U10 HD27904/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Narcotics; 50-36-2/Cocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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