Document Detail


Is maternal influenza or fever during pregnancy associated with autism or developmental delays? Results from the CHARGE (CHildhood Autism Risks from Genetics and Environment) study.
MedLine Citation:
PMID:  22562209     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We analyzed data from case groups of 538 children with autism spectrum disorders (ASD) and 163 with developmental delays (DD), and from 421 typically developing controls to assess associations with maternal influenza or fever during pregnancy. Exposure information was obtained by telephone interviews, and outcomes were clinically confirmed. Though neither ASD nor DD was associated with influenza, both were associated with maternal fever during pregnancy: OR's (odds ratios) were 2.12 (95 % CI 1.17, 3.84) and 2.50 (95 % CI 1.20, 5.20) respectively. However, the fever-associated ASD risk was attenuated among mothers who reported taking antipyretic medications (OR = 1.30, 95 % CI 0.59, 2.84), but remained elevated for those who did not (OR = 2.55, 95 % CI 1.30, 4.99).
Authors:
Ousseny Zerbo; Ana-Maria Iosif; Cheryl Walker; Sally Ozonoff; Robin L Hansen; Irva Hertz-Picciotto
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of autism and developmental disorders     Volume:  43     ISSN:  1573-3432     ISO Abbreviation:  J Autism Dev Disord     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-04     Completed Date:  2013-06-28     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  7904301     Medline TA:  J Autism Dev Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  25-33     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Antipyretics / adverse effects,  therapeutic use
Autistic Disorder / etiology*
Child Development Disorders, Pervasive / etiology
Child, Preschool
Developmental Disabilities / etiology*
Female
Fever / complications*,  drug therapy
Humans
Influenza, Human / complications*
Male
Odds Ratio
Pregnancy
Pregnancy Complications, Infectious / virology*
Prenatal Exposure Delayed Effects / psychology*
Risk
Young Adult
Grant Support
ID/Acronym/Agency:
P01 ES011269/ES/NIEHS NIH HHS; P01-ES11269/ES/NIEHS NIH HHS; R01 ES015359/ES/NIEHS NIH HHS; R01-ES015359/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Antipyretics
Comments/Corrections

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