| Maternal high-fat diet disturbs uteroplacental hemodynamics and increases the frequency of stillbirth in a nonhuman primate model of excess nutrition. | |
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MedLine Citation:
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PMID: 21447636 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prepregnancy maternal obesity confers an increased risk of stillbirth, but the mechanisms are unknown. Maternal obesity is associated with placental inflammation. We considered that maternal diet may predispose to the increased risk of placental inflammation and stillbirth. We hypothesized that a chronic high-fat diet (HFD) is associated with abnormal uteroplacental circulation and placental inflammation. Here we used a nonhuman primate model to determine the effect of chronic HFD on the uterine and placental hemodynamics, placental histology, and inflammation in a prospective, observational study of 24 Japanese macaques. Overall, there was a statistically significant (38-56%) reduction in uterine volume blood flow from HFD animals, whether they were lean or obese. Consumption of a HFD, independent of obesity, increased placental inflammatory cytokines and the expression of Toll-like receptor 4. We show that HFD consumption by obese mothers with hyperinsulinemia also reduced volume blood flow on the fetal side of the placenta and significantly increased the frequency of both placental infarctions and stillbirth. These results suggest that a HFD, independent of obesity, decreases uterine volume blood flow. Maternal obesity and insulin resistance further exacerbates the placental dysfunction and results in an increased frequency of stillbirth. |
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Authors:
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Antonio E Frias; Terry K Morgan; Anne E Evans; Juha Rasanen; Karen Y Oh; Kent L Thornburg; Kevin L Grove |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-03-29 |
Journal Detail:
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Title: Endocrinology Volume: 152 ISSN: 1945-7170 ISO Abbreviation: Endocrinology Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-23 Completed Date: 2011-11-22 Revised Date: 2012-05-15 |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: United States |
Other Details:
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Languages: eng Pagination: 2456-64 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon 97239, USA. friasa@ohsu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cytokines / genetics, immunology Dietary Fats / adverse effects*, immunology Disease Models, Animal Female Hemodynamics Humans Macaca Obesity / complications*, genetics, immunology, physiopathology Placenta / blood supply*, immunology Pregnancy Pregnancy Complications / genetics, immunology, physiopathology* Prenatal Nutritional Physiological Phenomena* Regional Blood Flow Stillbirth / epidemiology* Uterus / blood supply*, immunology |
| Grant Support | |
ID/Acronym/Agency:
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K12 HD001243-10/HD/NICHD NIH HHS; K12 HD043488-06/HD/NICHD NIH HHS; P01 HD34430/HD/NICHD NIH HHS; P51 RR00163/RR/NCRR NIH HHS; R01 DK-79194/DK/NIDDK NIH HHS; R24 DK090964/DK/NIDDK NIH HHS; R24 DK090964-02/DK/NIDDK NIH HHS; R24 DK0909640-01/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Dietary Fats |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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