Document Detail

Maternal Hemodynamics at 11-13 Weeks' Gestation in Gestational Diabetes Mellitus.
MedLine Citation:
PMID:  22572717     Owner:  NLM     Status:  Publisher    
Objective: Women who develop gestational diabetes mellitus (GDM) are at increased risk of type 2 diabetes and subsequent cardiovascular mortality and morbidity. Individuals with cardiovascular disorders have increased central aortic systolic blood pressure (SBP(Ao)) and arterial stiffness. The hypothesis of this study is that increased SBP(Ao) and arterial stiffness are apparent before the development of GDM. Methods: In this screening study, SBP(Ao), pulse wave velocity (PWV) and augmentation index (AIx) were measured in women with singleton pregnancies attending for routine antenatal care at 11-13 weeks' gestation. We compared SBP(Ao), PWV and AIx, expressed as multiples of the median (MoM), after adjustment for maternal characteristics affecting these measurements, in women who subsequently developed GDM (n = 105) with the values in non-GDM controls (n = 6,736). Results: In the GDM group, compared to non-GDM controls, there was an increase in PWV [1.04 MoM, interquartile range (IQR) 0.93-1.15 vs. 1.00 MoM, IQR 0.90-1.12; p = 0.013] and SBP(Ao) (1.03 MoM, IQR 0.98-1.14 vs. 1.00 MoM, IQR 0.94-1.08; p < 0.0001) but no significant difference in the AIx (1.02 MoM, IQR 0.89-1.22 vs. 1.00 MoM, IQR 0.87-1.17; p = 0.118). Conclusion: Women who develop GDM have increased SBP(Ao) and arterial stiffness from the first trimester of pregnancy before the clinical onset of GDM.
Asma Khalil; Rosario Garcia-Mandujano; Roxana Chiriac; Ranjit Akolekar; Kypros H Nicolaides
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-03
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  -     ISSN:  1421-9964     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Department of Fetal Medicine, Institute for Women's Health, University College London Hospitals, London, UK.
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