Document Detail

Maternal Hb during pregnancy and offspring's educational achievement: a prospective cohort study over 30 years.
MedLine Citation:
PMID:  20522275     Owner:  NLM     Status:  MEDLINE    
The aim of the present study was to examine the association between maternal Hb levels during pregnancy and educational achievement of the offspring in later life. We analysed data obtained from the Northern Finnish Birth Cohort Study conducted in 1966, in which, data on mothers and offspring from pregnancy through to the age of 31 years were collected. The cohort comprised 11 656 individuals born from singleton births (51 % males and 49 % females). Maternal Hb levels were available from the third, seventh and ninth gestational months. Educational achievement was measured as school scores (range 4-10) taken at the ages of 14 (self-reported questionnaires) and 16 (school reports) years as well as the highest level of education at the age of 31 years. The present results showed a direct positive association between Hb levels and educational achievement in later life. After adjustment for sex, birth weight, birth month and a wide range of maternal factors (parity, smoking, mental status, whether pregnancy was wanted or not, education, social class and marital status), only maternal Hb levels that were measured at the ninth month were significantly associated with the offspring's school performance. If the levels were ≥ 110 g/l at all the three measurement points, offspring not only had better school scores at the ages of 14 and 16 years (β = 0·048, P = 0·04 and β = 0·68, P = 0·007, respectively), but also had an increased odds of having a higher level of education at the age of 31 years (OR = 1·14, P = 0·04). The present study suggests that low maternal Hb levels at the final stages of pregnancy are linked to the poorer educational achievement of the offspring. If our observation is confirmed, it would suggest that Fe prophylaxis even at fairly late stages of pregnancy may be beneficial for the subsequent health of the offspring. However, more studies are needed to fully establish the potential pathways and the clinical importance of the present findings.
Mohammad Fararouei; Claire Robertson; John Whittaker; Ulla Sovio; Aimo Ruokonen; Anneli Pouta; Anna-Liisa Hartikainen; Marjo-Riitta Jarvelin; Elina Hyppönen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-04
Journal Detail:
Title:  The British journal of nutrition     Volume:  104     ISSN:  1475-2662     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-29     Completed Date:  2010-11-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  1363-8     Citation Subset:  IM    
Faculty of Health, Yasuj University of Medical Sciences, Yasuj, Iran.
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MeSH Terms
Anemia, Iron-Deficiency / blood*,  complications
Educational Status*
Gestational Age
Hemoglobins / metabolism*
Odds Ratio
Pregnancy / blood*
Pregnancy Complications / blood*
Prenatal Exposure Delayed Effects*
Prospective Studies
Young Adult
Grant Support
//Department of Health
Reg. No./Substance:

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