Document Detail

Maternal HBsAg status and infant size--a Faustian bargain?
MedLine Citation:
PMID:  22676365     Owner:  NLM     Status:  MEDLINE    
Information on the impact of maternal hepatitis B virus (HBV) infection on pregnancy outcome is conflicting. Some studies reported an association with increased infant birthweight, which could be interpreted as advantageous to pregnancy. A retrospective study was performed to compare birthweight outcome between 6261 and 55,817 singleton pregnancies in mothers screened positive and negative for hepatitis B surface antigen (HBsAg), respectively. The HBsAg positive women were younger, had higher body mass index (BMI) and incidence of overweight, but less gestational weight gain, and were associated with increased macrosomia (birthweight ≥4000 g) in mothers <35 years (odds ratio, OR, 1.28), BMI ≥25 kg/m(2) (OR 1.24), without gestational diabetes mellitus (GDM, OR 1.19), and in male infants (OR 1.18). It was also associated with increased large-for-gestational age (LGA, birthweight >90th percentile) infants in nulliparas (OR 1.13), age <35 years (OR 1.12), BMI ≥25 kg/m(2) (OR 1.19), with (OR 1.36) and without (OR 1.09) GDM, and in male infants (OR 1.13). When the effects of high BMI, advanced age, GDM, and male infants were controlled for, positive HBsAg was significantly associated with macrosomic (adjusted odds ratio, aOR, 1.15) and LGA (aOR 1.11) infants. In view of the latest findings on the association between high infant birthweight with increased risk of obesity, diabetes mellitus, and various forms of malignancies from childhood to adulthood, further studies are warranted to determine if maternal hepatitis B infection would impact adversely on the long-term health of the offspring through its effect on increasing birthweight.
T T Lao; D S Sahota; S S H Suen; L W Law; T Y Leung
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2012-01-28
Journal Detail:
Title:  Journal of viral hepatitis     Volume:  19     ISSN:  1365-2893     ISO Abbreviation:  J. Viral Hepat.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-08     Completed Date:  2012-09-28     Revised Date:  2013-06-19    
Medline Journal Info:
Nlm Unique ID:  9435672     Medline TA:  J Viral Hepat     Country:  England    
Other Details:
Languages:  eng     Pagination:  519-24     Citation Subset:  IM    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
Department of Obstetrics & Gynaecology, The Chinese University of Hong Kong, and Prince of Wales Hospital, Shatin, Hong Kong.
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MeSH Terms
Birth Weight / physiology
Fetal Macrosomia / epidemiology*
Hepatitis B / complications*,  diagnosis*
Hepatitis B Surface Antigens / blood*
Pregnancy Complications, Infectious / diagnosis*,  virology*
Pregnancy Outcome*
Retrospective Studies
Reg. No./Substance:
0/Hepatitis B Surface Antigens
Comment In:
J Viral Hepat. 2013 Jun;20(6):444   [PMID:  23647962 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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