Document Detail


Maternal flow-mediated dilation and nitrite concentration during third trimester of pregnancy and postpartum period.
MedLine Citation:
PMID:  23782031     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To compare maternal flow-mediated dilation (FMD) of the brachial artery and nitrite concentration between third trimester of pregnancy (3rdT) and postpartum (PP) period. Additionally, we will evaluate whether FMD correlates with nitrite concentration in both periods.
METHODS: Eligibility criteria was healthy women with singleton pregnancy, gestational age >28 weeks, nonsmokers, and no personal or family history of vascular disease. Each women was examined during 3rdT and between 8 and 12 weeks PP to evaluate FMD and nitrite concentration in whole blood. Women not examined in both periods were excluded. Values between both periods were compared using paired t tests. Correlation between FMD and nitrite was examined by Pearson correlation coefficient. Significance level set as p < 0.05.
RESULTS: We invited 42 pregnant women. Among them, 35 were eligible and 7 of them were excluded for not attending the PP evaluation resulting in 28 participants analyzed. We found no significant change in FMD (10.39 ± 5.57% vs. 8.42 ± 4.21%; p = 0.11; 3rdT vs. PP, respectively) and no significant change in nitrite concentration (257.41 ± 122.95 nmol/L vs. 237.16 ± 90.01 nmol/L; p = 0.28). Baseline brachial artery diameter had a significant reduction (3.11 ± 0.30 to 2.75 ± 0.34 mm; p < 0.01). No significant correlation between FMD and nitrite during 3rdT (r = -0.13; p = 0.50) or PP (r = 0.14; p = 0.48) was found.
CONCLUSIONS: We did not observe significant changes in both FMD and nitrite concentration between third trimester and the PP period. FMD did not correlate with nitrite in both periods. More studies are needed to confirm our findings.
Authors:
Andre H Miyague; Wellington P Martins; Jaqueline S R Machado; Ana C Palei; Lorena M Amaral; Danielle M Teixeira; Valeria C Sandrim; Jonas T C Sertorio; Jose E Tanus-Santos; Geraldo Duarte; Ricardo C Cavalli
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2013-06-19
Journal Detail:
Title:  Hypertension in pregnancy     Volume:  32     ISSN:  1525-6065     ISO Abbreviation:  Hypertens Pregnancy     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-08-02     Completed Date:  2014-07-14     Revised Date:  2014-07-23    
Medline Journal Info:
Nlm Unique ID:  9421297     Medline TA:  Hypertens Pregnancy     Country:  England    
Other Details:
Languages:  eng     Pagination:  225-34     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Endothelium, Vascular / physiology*
Female
Humans
Nitrites / blood*
Postpartum Period / physiology*
Pregnancy / physiology*
Pregnancy Trimester, Third / physiology*
Prospective Studies
Vasodilation
Young Adult
Chemical
Reg. No./Substance:
0/Nitrites

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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