| Maternal and fetal thrombophilia in intrauterine growth restriction in the presence or absence of maternal hypertensive disease. | |
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MedLine Citation:
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PMID: 20601540 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intrauterine growth restriction (IUGR) depends on the placental capacity to transfer oxygen and nutrients from the maternal to the fetal circulation. Placental insufficiency may be caused by impairment of the maternal or fetal circulation by a thrombotic event, possibly associated with thrombophilic disorders. The goals of our study were to define the role of maternal/fetal gain-of-function factor V Leiden and prothrombin G20210A mutations in the development of IUGR and to evaluate whether maternal pregnancy-induced hypertensive diseases would modify any such association. This is a case-control study: controls were 259 normal pregnancies, cases were 77 IUGR, 28 with and 49 without preeclampsia (PE) or pregnancy-induced hypertension (PIH). An association was found between IUGR and fetal thrombophilia (OR 2.09 CI 95% 1-4.5). The association was stronger in IUGR without PE and PIH (OR 2.9 CI 95% 1.3-6.6). This suggests a role for the fetal genotype in the development of IUGR. |
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Authors:
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Paola Pileri; Franca Franchi; Irene Cetin; Chiara Mandò; Patrizio Antonazzo; Buthaina Ibrahim; Federica Rossi; Eugenia Biguzzi |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-02 |
Journal Detail:
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Title: Reproductive sciences (Thousand Oaks, Calif.) Volume: 17 ISSN: 1933-7205 ISO Abbreviation: Reprod Sci Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-11 Completed Date: 2010-11-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101291249 Medline TA: Reprod Sci Country: United States |
Other Details:
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Languages: eng Pagination: 844-8 Citation Subset: IM |
Affiliation:
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Department of Clinical Sciences, Hospital Luigi Sacco, Department of Medicine and Medical Specialties, University of Milan, Milan, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Pressure Case-Control Studies Chi-Square Distribution Factor V / genetics* Female Fetal Diseases / genetics* Fetal Growth Retardation / etiology*, genetics, physiopathology Genotype Humans Hypertension, Pregnancy-Induced / physiopathology* Italy Logistic Models Mutation Odds Ratio Phenotype Placental Circulation Pre-Eclampsia / physiopathology Pregnancy Pregnancy Complications, Hematologic / genetics* Prothrombin / genetics* Risk Assessment Risk Factors Thrombophilia / genetics* |
| Chemical | |
Reg. No./Substance:
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0/factor V Leiden; 9001-24-5/Factor V; 9001-26-7/Prothrombin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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