Document Detail


Maternal and fetal placental growth hormone and IGF axis in type 1 diabetic pregnancy.
MedLine Citation:
PMID:  22363400     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: Placental growth hormone (PGH) is a major growth hormone in pregnancy and acts with Insulin Like Growth Factor I (IGF-I) and Insulin Like Growth Hormone Binding Protein 3 (IGFBP3). The aim of this study was to investigate PGH, IGF-I and IGFBP3 in non-diabetic (ND) compared to Type 1 Diabetic (T1DM) pregnancies.
METHODS: This is a prospective study. Maternal samples were obtained from 25 ND and 25 T1DM mothers at 36 weeks gestation. Cord blood was obtained after delivery. PGH, IGF-I and IGFBP3 were measured using ELISA.
RESULTS: There was no difference in delivery type, gender of infants or birth weight between groups. In T1DM, maternal PGH significantly correlated with ultrasound estimated fetal weight (r = 0.4, p = 0.02), birth weight (r = 0.51, p<0.05) and birth weight centile (r = 0.41, p = 0.03) PGH did not correlate with HbA1c. Maternal IGF-I was lower in T1DM (p = 0.03). Maternal and fetal serum IGFBP3 was higher in T1DM. Maternal third trimester T1DM serum had a significant band at 16 kD on western blot, which was not present in ND.
CONCLUSION: Maternal T1DM PGH correlated with both antenatal fetal weight and birth weight, suggesting a significant role for PGH in growth in diabetic pregnancy. IGFBP3 is significantly increased in maternal and fetal serum in T1DM pregnancies compared to ND controls, which was explained by increased proteolysis in maternal but not fetal serum. These results suggest that the normal PGH-IGF-I-IGFBP3 axis in pregnancy is abnormal in T1DM pregnancies, which are at higher risk of macrosomia.
Authors:
Mary F Higgins; Noirin E Russell; Paul A Crossey; Kristine C Nyhan; Derek P Brazil; Fionnuala M McAuliffe
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-02-17
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-02-24     Completed Date:  2012-06-29     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e29164     Citation Subset:  IM    
Affiliation:
UCD Obstetrics and Gynaecology, School of Medicine and Medical Science, University College Dublin, National Maternity Hospital, Dublin, Ireland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Birth Weight
Blotting, Western
Diabetes Mellitus, Type 1 / blood*
Female
Fetus / metabolism*
Growth Hormone / blood*
Humans
Immunoblotting
Insulin-Like Growth Factor Binding Protein 3 / blood*
Insulin-Like Growth Factor I / metabolism*
Placenta / metabolism
Placental Hormones / blood*
Pregnancy
Pregnancy in Diabetics / blood*
Ultrasonography, Prenatal
Young Adult
Chemical
Reg. No./Substance:
0/GH2 protein, human; 0/Insulin-Like Growth Factor Binding Protein 3; 0/Placental Hormones; 67763-96-6/Insulin-Like Growth Factor I; 9002-72-6/Growth Hormone
Comments/Corrections
Erratum In:
PLoS One. 2012;7(5). doi:10.1371/annotation/b3c08210-a703-4986-aa97-c8513c5aff5f

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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