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Maternal and Fetal Leptin, Adiponectin Levels and Associations with Fetal Insulin Sensitivity.
MedLine Citation:
PMID:  22739586     Owner:  NLM     Status:  Publisher    
It remains uncertain whether leptin and adiponectin levels are correlated in maternal versus fetal circulations. Little is known about whether leptin and adiponectin affect insulin sensitivity during fetal life. In a prospective singleton pregnancy cohort (n=248), we investigated leptin and adiponectin concentrations in maternal (at 24-28 weeks and 32-35 weeks of gestation) and fetal circulations, and their associations with fetal insulin sensitivity (glucose/insulin ratio, proinsulin level). Comparing concentrations in cord versus maternal blood, leptin levels were 50% lower, but adiponectin levels more than doubled. Adjusting for gestational age at blood sampling, consistent and similar positive correlations (correlation coefficients: 0.31 to 0.34, all p<0.0001) were observed in leptin or adiponectin levels in maternal (at 24-28 or 32-25 weeks of gestation) versus fetal circulations. For each standard deviation (SD) increase in maternal plasma concentration at 24-28 weeks, cord plasma concentration increased by 12.7 (95% confidence interval 6.8-18.5) ng/ml for leptin, and 2.9 (1.8-4.0) g/ml for adiponectin, respectively (adjusted p<0.0001). Fetal insulin sensitivity was negatively associated with cord blood leptin [each SD increase was associated with a 5.4 (2.1-8.7) mg/dl/ μU/ml reduction in cord plasma glucose/insulin ratio, and a 5.6 (3.9, 7.4) pmol/l increase in proinsulin level, all adjusted p<0.01] but not adiponectin (p>0.4) levels. Similar associations were observed in non-diabetic full-term pregnancies (n=211). The results consistently suggest a maternal impact on fetal leptin and adiponectin levels, which may be an early life pathway in maternal-fetal transmission of the propensity to obesity and insulin resistance.
Zhong-Cheng Luo; Anne-Monique Nuyt; Edgard Delvin; William D Fraser; Pierre Julien; Francois Audibert; Isabelle Girard; Bryna Shatenstein; Cheri Deal; Emilie Grenier; Carole Grenier; Emile Levy
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-28
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  -     ISSN:  1930-7381     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Obstetrics and Gynecology, CHU Sainte Justine, University of Montreal, Montreal, Canada.
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