Document Detail


Maternal and Fetal Leptin, Adiponectin Levels and Associations with Fetal Insulin Sensitivity.
MedLine Citation:
PMID:  22739586     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
It remains uncertain whether leptin and adiponectin levels are correlated in maternal versus fetal circulations. Little is known about whether leptin and adiponectin affect insulin sensitivity during fetal life. In a prospective singleton pregnancy cohort (n=248), we investigated leptin and adiponectin concentrations in maternal (at 24-28 weeks and 32-35 weeks of gestation) and fetal circulations, and their associations with fetal insulin sensitivity (glucose/insulin ratio, proinsulin level). Comparing concentrations in cord versus maternal blood, leptin levels were 50% lower, but adiponectin levels more than doubled. Adjusting for gestational age at blood sampling, consistent and similar positive correlations (correlation coefficients: 0.31 to 0.34, all p<0.0001) were observed in leptin or adiponectin levels in maternal (at 24-28 or 32-25 weeks of gestation) versus fetal circulations. For each standard deviation (SD) increase in maternal plasma concentration at 24-28 weeks, cord plasma concentration increased by 12.7 (95% confidence interval 6.8-18.5) ng/ml for leptin, and 2.9 (1.8-4.0) g/ml for adiponectin, respectively (adjusted p<0.0001). Fetal insulin sensitivity was negatively associated with cord blood leptin [each SD increase was associated with a 5.4 (2.1-8.7) mg/dl/ μU/ml reduction in cord plasma glucose/insulin ratio, and a 5.6 (3.9, 7.4) pmol/l increase in proinsulin level, all adjusted p<0.01] but not adiponectin (p>0.4) levels. Similar associations were observed in non-diabetic full-term pregnancies (n=211). The results consistently suggest a maternal impact on fetal leptin and adiponectin levels, which may be an early life pathway in maternal-fetal transmission of the propensity to obesity and insulin resistance.
Authors:
Zhong-Cheng Luo; Anne-Monique Nuyt; Edgard Delvin; William D Fraser; Pierre Julien; Francois Audibert; Isabelle Girard; Bryna Shatenstein; Cheri Deal; Emilie Grenier; Carole Grenier; Emile Levy
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-28
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  -     ISSN:  1930-7381     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Obstetrics and Gynecology, CHU Sainte Justine, University of Montreal, Montreal, Canada.
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