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Maternal and Fetal IGF-I and IGF-II Levels, Fetal Growth, and Gestational Diabetes.
MedLine Citation:
PMID:  22419731     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Context:It remains uncertain whether maternal IGF-I is associated with fetal growth. Little is known about the role of maternal IGF-II in fetal growth and whether IGF-I or IGF-II is implicated in fetal hypertrophy in gestational diabetes.Objective:The objective of the study was to assess maternal and fetal IGF-I and IGF-II levels in association with fetal growth and gestational diabetes.Study Design, Population, and Outcomes:A singleton pregnancy cohort study (n = 307). The primary outcome was birth weight.Results:Maternal plasma concentrations increased by an average of 55.4% for IGF-I and 11.8% for IGF-II between 24-28 and 32-35 weeks of gestation. The maternal IGF-I but not IGF-II level was correlated with birth weight and placental weight. Adjusting for maternal and infant characteristics, each sd increase in maternal IGF-I level at 24-28 weeks was associated with a 75-g (95% confidence intervals 29-120) increase in birth weight, a 20-g (7-33) increase in placental weight, and a 1.91-fold (1.28-2.86) higher odds of macrosomia (birth weight > 90th percentile). Similar associations were observed for the maternal IGF-I level at 32-35 weeks. Maternal and fetal IGF-I (but not IGF-II) levels were significantly higher in gestational diabetic than in nondiabetic pregnancies. The significantly higher birth weight z scores in diabetic pregnancies disappeared after adjusting for maternal and fetal IGF-I levels alone.Conclusions:Higher maternal IGF-I (but not IGF-II) levels at mid- and late gestation may indicate greater placental and fetal growth. IGF-I (but not IGF-II) may be implicated in fetal hypertrophy in gestational diabetes.
Authors:
Zhong-Cheng Luo; Anne-Monique Nuyt; Edgard Delvin; Francois Audibert; Isabelle Girard; Bryna Shatenstein; Anik Cloutier; Jocelyne Cousineau; Anissa Djemli; Cheri Deal; Emile Levy; Yuquan Wu; Pierre Julien; William D Fraser
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-14
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  -     ISSN:  1945-7197     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Obstetrics and Gynecology (Z.-C.L., F.A., W.D.F., Y.W.), Centre Hospitalier Universitaire Sainte Justine, and Departments of Pediatrics (A.-M.N., A.C., C.D.), Biochemistry (E.D., J.C., A.D.), and Nutrition (B.S., E.L.), University of Montréal, Montréal, Canada H3T 1C5; Department of Obstetrics and Gynecology (I.G.), McGill University, Montréal, Québec, Canada H9X 3V9; and Lipid Research Centre (P.J.), Laval University Health Centre, Québec, Canada G1V 4G2.
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