| Maternal fenvalerate exposure during pregnancy persistently impairs testicular development and spermatogenesis in male offspring. | |
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MedLine Citation:
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PMID: 20138952 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fenvalerate, a widely used pyrethroid insecticide, has been associated with poor semen quality. As yet, little is known about the effects of prenatal fenvalerate exposure on testicular development. The present study investigated the effects of prenatal fenvalerate exposure on testicular development and spermatogenesis. The pregnant mice were administered fenvalerate (30 mg/kg) by gavage daily from gestational day (gd) 13 to gd 18. The weights of testes and epididymides were significantly decreased in mice whose mothers were exposed to fenvalerate during pregnancy. Importantly, maternal fenvalerate exposure during pregnancy markedly decreased the number of mature seminiferous tubules (stages VII and VIII) in testes of adult male offspring. In addition, maternal fenvalerate exposure during pregnancy significantly reduced the number of epididymal spermatozoa in adult male offspring. Additional experiments showed that the level of serum testosterone (T) was significantly decreased in male fetuses whose mothers were exposed to fenvalerate during pregnancy. Correspondingly, mRNA and protein levels of P450(17alpha), a T synthetic enzyme, were significantly decreased in fetal testes. Moreover, the disruptive effect of prenatal fenvalerate exposure on testicular T synthesis was irreversible. In conclusion, prenatal fenvalerate exposure irreversibly impairs testicular development and spermatogenesis at least into early adulthood. |
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Authors:
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Heng Zhang; Hua Wang; Yan-Li Ji; Ying Zhang; Tao Yu; Huan Ning; Cheng Zhang; Xian-Feng Zhao; Qun Wang; Ping Liu; De-Xiang Xu |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-02-06 |
Journal Detail:
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Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Volume: 48 ISSN: 1873-6351 ISO Abbreviation: Food Chem. Toxicol. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-14 Completed Date: 2010-07-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8207483 Medline TA: Food Chem Toxicol Country: England |
Other Details:
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Languages: eng Pagination: 1160-9 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Toxicology, Anhui Medical University, Hefei 230032, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Epididymis / drug effects, pathology Female Fetal Development / drug effects* Gene Expression Regulation, Developmental / drug effects Insecticides / toxicity* Male Maternal Exposure Mice Mice, Inbred Strains Nitriles / toxicity* Organ Size / drug effects Pregnancy Prenatal Exposure Delayed Effects Pyrethrins / toxicity* Spermatogenesis / drug effects* Steroid 17-alpha-Hydroxylase / genetics, metabolism Testis / drug effects*, embryology, enzymology Testosterone / biosynthesis |
| Chemical | |
Reg. No./Substance:
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0/Insecticides; 0/Nitriles; 0/Pyrethrins; 51630-58-1/fenvalerate; 58-22-0/Testosterone; EC 1.14.99.9/Steroid 17-alpha-Hydroxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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