Document Detail

Maternal exposure to particulate matter increases postnatal ozone-induced airway hyperreactivity in juvenile mice.
MedLine Citation:
PMID:  19762564     Owner:  NLM     Status:  MEDLINE    
RATIONALE: Epidemiologic studies implicate air pollutant exposure during pregnancy as a risk factor for wheezing in offspring. Ozone exposure is linked to exacerbations of wheezing in children.
OBJECTIVES: To determine if maternal pulmonary exposure to traffic-related particles during pregnancy augments ozone-induced airway hyperresponsiveness in offspring.
METHODS: C57BL6 time-mated mice were given NIST SRM#1648 (particulate matter [PM]) 0.48 mg, saline vehicle, or no treatment by tracheal insufflation twice weekly for 3 weeks. PM exposure augmented maternal lung inflammation and placental TNF-alpha, Keratinocyte-derived cytokine (KC), and IL-6 (measured at gestation Day 18). After parturition, dams and litters were exposed to air or ozone 1 ppm 3 h/d, every other day, thrice weekly for 4 weeks. Respiratory system resistance in pups was measured at baseline and after administration of nebulized methacholine.
MEASUREMENTS AND MAIN RESULTS: Ozone increased airway hyperresponsiveness, but the increase was greatest in pups born to PM-treated dams. Whole-lung TNF-alpha, IL-1beta, KC, IL-6, and MCP-1 were increased in ozone-treated pups, with the greatest increase in pups born to dams given PM. Airway epithelial mucous metaplasia estimated by periodic acid-Schiff Alcian blue staining was increased in ozone-exposed pups born to PM-treated dams. Alveolar development, determined by morphometry, and airway smooth muscle bulk, estimated using alpha-actin histochemistry, were unaffected by prenatal or postnatal treatment.
CONCLUSIONS: Maternal pulmonary exposure to PM during pregnancy augments placental cytokine expression and postnatal ozone-induced pulmonary inflammatory cytokine responses and ozone-induced airway hyperresponsiveness without altering airway structure.
Richard L Auten; Erin N Potts; S Nicholas Mason; Bernard Fischer; Yuhchin Huang; W Michael Foster
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-09-17
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  180     ISSN:  1535-4970     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-01     Completed Date:  2010-01-04     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1218-26     Citation Subset:  AIM; IM    
Neonatal Medicine, Department of Pediatrics, Duke University, Durham, North Carolina, USA.
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MeSH Terms
Air Pollutants / toxicity
Air Pollution
Analysis of Variance
Bronchial Hyperreactivity / chemically induced*,  physiopathology
Bronchial Provocation Tests
Bronchoalveolar Lavage Fluid
Disease Models, Animal
Inflammation / chemically induced,  physiopathology
Inhalation Exposure
Lung / physiopathology
Maternal Exposure*
Maternal-Fetal Exchange
Mice, Inbred C57BL
Oxidants, Photochemical / toxicity*
Ozone / toxicity*
Particulate Matter / toxicity*
Prenatal Exposure Delayed Effects / chemically induced*
Respiratory Function Tests
Grant Support
Reg. No./Substance:
0/Air Pollutants; 0/Oxidants, Photochemical; 0/Particulate Matter; 10028-15-6/Ozone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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