| Maternal exposure to particulate matter increases postnatal ozone-induced airway hyperreactivity in juvenile mice. | |
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MedLine Citation:
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PMID: 19762564 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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RATIONALE: Epidemiologic studies implicate air pollutant exposure during pregnancy as a risk factor for wheezing in offspring. Ozone exposure is linked to exacerbations of wheezing in children. OBJECTIVES: To determine if maternal pulmonary exposure to traffic-related particles during pregnancy augments ozone-induced airway hyperresponsiveness in offspring. METHODS: C57BL6 time-mated mice were given NIST SRM#1648 (particulate matter [PM]) 0.48 mg, saline vehicle, or no treatment by tracheal insufflation twice weekly for 3 weeks. PM exposure augmented maternal lung inflammation and placental TNF-alpha, Keratinocyte-derived cytokine (KC), and IL-6 (measured at gestation Day 18). After parturition, dams and litters were exposed to air or ozone 1 ppm 3 h/d, every other day, thrice weekly for 4 weeks. Respiratory system resistance in pups was measured at baseline and after administration of nebulized methacholine. MEASUREMENTS AND MAIN RESULTS: Ozone increased airway hyperresponsiveness, but the increase was greatest in pups born to PM-treated dams. Whole-lung TNF-alpha, IL-1beta, KC, IL-6, and MCP-1 were increased in ozone-treated pups, with the greatest increase in pups born to dams given PM. Airway epithelial mucous metaplasia estimated by periodic acid-Schiff Alcian blue staining was increased in ozone-exposed pups born to PM-treated dams. Alveolar development, determined by morphometry, and airway smooth muscle bulk, estimated using alpha-actin histochemistry, were unaffected by prenatal or postnatal treatment. CONCLUSIONS: Maternal pulmonary exposure to PM during pregnancy augments placental cytokine expression and postnatal ozone-induced pulmonary inflammatory cytokine responses and ozone-induced airway hyperresponsiveness without altering airway structure. |
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Authors:
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Richard L Auten; Erin N Potts; S Nicholas Mason; Bernard Fischer; Yuhchin Huang; W Michael Foster |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-09-17 |
Journal Detail:
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Title: American journal of respiratory and critical care medicine Volume: 180 ISSN: 1535-4970 ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-01 Completed Date: 2010-01-04 Revised Date: 2010-12-16 |
Medline Journal Info:
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Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 1218-26 Citation Subset: AIM; IM |
Affiliation:
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Neonatal Medicine, Department of Pediatrics, Duke University, Durham, North Carolina, USA. auten@duke.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Air Pollutants
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toxicity Air Pollution Analysis of Variance Animals Bronchial Hyperreactivity / chemically induced*, physiopathology Bronchial Provocation Tests Bronchoalveolar Lavage Fluid Disease Models, Animal Female Inflammation / chemically induced, physiopathology Inhalation Exposure Lung / physiopathology Maternal Exposure* Maternal-Fetal Exchange Mice Mice, Inbred C57BL Oxidants, Photochemical / toxicity* Ozone / toxicity* Particulate Matter / toxicity* Pregnancy Prenatal Exposure Delayed Effects / chemically induced* Respiratory Function Tests |
| Grant Support | |
ID/Acronym/Agency:
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ES-011961/ES/NIEHS NIH HHS; ES-016347/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Air Pollutants; 0/Oxidants, Photochemical; 0/Particulate Matter; 10028-15-6/Ozone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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