Document Detail


Maternal dietary patterns during early pregnancy and the odds of childhood germ cell tumors: A Children's Oncology Group study.
MedLine Citation:
PMID:  21098631     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Maternal diet during pregnancy may be associated with cancer in offspring. Intake of individual foods, as well as dietary patterns, can be used when examining these relations. Here, the authors examined associations between maternal dietary intake patterns and pediatric germ cell tumors (GCTs) using principal components analysis and logistic regression. Mothers of 222 GCT cases aged less than 15 years who were diagnosed at a Children's Oncology Group institution between 1993 and 2001 and those of 336 frequency-matched controls completed a self-administered food frequency questionnaire of diet during early pregnancy. Four dietary patterns were identified: "Western," "fruits and vegetables," "protein," and "healthful." With adjustment for birth weight, parity, and vitamin use, the fruits and vegetables pattern was significantly associated with a lower odds for GCTs (odds ratio (OR) = 0.83, 95% confidence interval (CI): 0.69, 0.99; 2 sided). Upon stratification, the fruits and vegetables pattern was significantly associated with a lower odds in males (OR = 0.66, 95% CI: 0.47, 0.92) but not females (OR = 0.91, 95% CI: 0.72, 1.14). A quantitative assessment of assumed nondifferential reporting error indicated no notable deviations from unadjusted odds ratio estimates. Results of this exploratory analysis suggest that maternal prenatal dietary patterns could be considered in future studies of GCTs in offspring.
Authors:
Jessica R B Musselman; Anne M Jurek; Kimberly J Johnson; Amy M Linabery; Leslie L Robison; Xiao-Ou Shu; Julie A Ross
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-11-23
Journal Detail:
Title:  American journal of epidemiology     Volume:  173     ISSN:  1476-6256     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-21     Completed Date:  2011-02-23     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  282-91     Citation Subset:  IM    
Affiliation:
University of Minnesota, Minneapolis, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Case-Control Studies
Child
Child, Preschool
Diet* / adverse effects
Eating
Female
Fruit
Humans
Infant
Infant, Newborn
Logistic Models
Male
Maternal Behavior
Neoplasms, Germ Cell and Embryonal / embryology,  etiology*,  pathology,  prevention & control*
Odds Ratio
Pregnancy
Prenatal Exposure Delayed Effects / epidemiology*
Prenatal Nutritional Physiological Phenomena*
Questionnaires
Risk Factors
Sex Factors
United States / epidemiology
Vegetables
Grant Support
ID/Acronym/Agency:
R01 CA067263/CA/NCI NIH HHS; R01 CA067263/CA/NCI NIH HHS; T32 CA099936/CA/NCI NIH HHS; T32 CA099936/CA/NCI NIH HHS; U10 CA098413/CA/NCI NIH HHS; U10 CA098543/CA/NCI NIH HHS; U10 CA98413/CA/NCI NIH HHS; U10 CA98543/CA/NCI NIH HHS
Comments/Corrections

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