Document Detail

Maternal dietary DHA supplementation to improve inflammatory outcomes in the preterm infant.
MedLine Citation:
PMID:  22585914     Owner:  NLM     Status:  MEDLINE    
Dietary DHA (22:6n-3) is a long-chain PUFA that has provocative effects on inflammatory signal events that could potentially affect preterm infant health. It is well known that the essential fatty acid of the (n-3) series; α-linolenic acid (18:3n:3) can be desaturated and elongated in the liver endoplasmic reticulum and peroxisome to produce the 22-carbon DHA. Nevertheless, concern exists as to the efficiency of this mechanism in providing the preterm infant with adequate DHA. Activity of the δ-6-desaturase and the δ-5-desaturase necessary for DHA synthesis is decreased by protein deprivation. The combined effects of suboptimal intake of both DHA and protein in the preterm infants could have substantial clinical consequences.
Christina J Valentine
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-05-01
Journal Detail:
Title:  Advances in nutrition (Bethesda, Md.)     Volume:  3     ISSN:  2156-5376     ISO Abbreviation:  Adv Nutr     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-15     Completed Date:  2012-10-01     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  101540874     Medline TA:  Adv Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  370-6     Citation Subset:  IM    
Division of Neonatology, Perinatal, and Pulmonary Biology, Center for Interdisciplinary Research in Human Milk and Lactation, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
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MeSH Terms
Clinical Trials as Topic
Dietary Supplements*
Docosahexaenoic Acids / administration & dosage*
Fatty Acids, Essential / administration & dosage
Infant, Newborn
Infant, Premature
Inflammation / drug therapy,  physiopathology
Liver / metabolism
Maternal Nutritional Physiological Phenomena
Milk, Human / chemistry*
Nutritional Requirements
alpha-Linolenic Acid / administration & dosage
Reg. No./Substance:
0/Fatty Acids, Essential; 25167-62-8/Docosahexaenoic Acids; 463-40-1/alpha-Linolenic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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