Document Detail

Maternal cytomegalovirus-specific immune responses and symptomatic postnatal cytomegalovirus transmission in very low-birth-weight preterm infants.
MedLine Citation:
PMID:  21984738     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Transmission of cytomegalovirus (CMV) via breast milk can lead to severe acute illness in very low-birth-weight (VLBW) preterm infants. Although the majority of CMV-seropositive women shed CMV in milk, symptomatic postnatal infection of VLBW infants occurs infrequently, suggesting that virologic or immunologic factors in milk may be associated with the risk and severity of postnatal CMV infection.
METHODS: We investigated the magnitude of CMV-specific cellular and humoral immune responses in milk of 30 seropositive mothers of VLWB preterm infants and assessed their relationship to milk CMV load and symptomatic CMV transmission.
RESULTS: Milk immunoglobulin G (IgG) avidity was inversely correlated to milk CMV load (r = -0.47; P = .009). However, milk CMV load and CMV-specific cellular and humoral immune responses were similar in mothers of VLBW infants with and those without symptomatic postnatal CMV infection.
CONCLUSIONS: Similar immunologic parameters in milk of CMV-seropositive mothers of VLBW infants with and without symptomatic postnatal CMV infection indicate that screening milk by these parameters may not predict disease risk. However, the inverse correlation between milk CMV IgG avidity and CMV load may suggest that enhancement of maternal CMV-specific IgG responses could aid in reduction of CMV shedding into breast milk.
Elizabeth P Ehlinger; Emily M Webster; Helen H Kang; Aislyn Cangialose; Adam C Simmons; Kimberly H Barbas; Sandra K Burchett; Mary L Gregory; Karen M Puopolo; Karen P Puopolo; Sallie R Permar
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-10-07
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  204     ISSN:  1537-6613     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-10-31     Completed Date:  2011-12-22     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1672-82     Citation Subset:  AIM; IM    
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
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MeSH Terms
Antibody Affinity / immunology
Breast Feeding / adverse effects
Cytomegalovirus / immunology*,  isolation & purification
Cytomegalovirus Infections / diagnosis,  immunology*,  transmission*
Gestational Age
Immunity, Cellular
Immunity, Humoral
Immunoglobulin A / immunology
Immunoglobulin G / immunology
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / diagnosis,  immunology*
Infant, Very Low Birth Weight / immunology*
Infectious Disease Transmission, Vertical*
Leukocyte Count
Milk, Human / immunology*,  virology
Viral Load / immunology
Young Adult
Grant Support
1 UL1 RR 025758-01/RR/NCRR NIH HHS
Reg. No./Substance:
0/Immunoglobulin A; 0/Immunoglobulin G
Erratum In:
J Infect Dis. 2012 Jun;205(11):1767
Note: Puopolo, Karen P [corrected to Puopolo, Karen M]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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