Document Detail

Maternal C-reactive protein and developmental programming of atherosclerosis.
MedLine Citation:
PMID:  18313449     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Maternal hypercholesterolemia during pregnancy enhances the susceptibility to atherosclerosis in their offspring by oxidation-dependent mechanisms. The present study investigated whether maternal C-reactive protein (CRP) level, which is an indicator of inflammation and cardiovascular risk, or smoking, which enhances oxidative stress, predict the in utero programming of atherosclerosis. STUDY DESIGN: Subsets of patients from the Fate of Early Lesions in Childhood study (156 normocholesterolemic children) were examined at autopsy, classified by maternal cholesterol levels during pregnancy. Maternal CRP level was correlated with maternal cholesterol and aortic atherosclerosis of children. RESULTS: CRP level was elevated in hypercholesterolemic mothers and showed significant correlation with atherogenesis in children in univariate and multivariate analysis. However, many hypercholesterolemic mothers did not have elevated CRP levels. Smoking only correlated in univariate analysis. CONCLUSION: CRP level during pregnancy is a predictor of increased atherogenesis in children of hypercholesterolemic mothers, albeit a weaker one than maternal cholesterol. In the presence of hypercholesterolemia, maternal smoking does not further enhance atherogenic programming.
Antonio Liguori; Francesco P D'Armiento; Antonio Palagiano; Wulf Palinski; Claudio Napoli
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  198     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-03     Completed Date:  2008-04-08     Revised Date:  2009-08-03    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  281.e1-5     Citation Subset:  AIM; IM    
Regional Hospital of Pellegrini, Naples, Italy.
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MeSH Terms
Atherosclerosis / embryology*,  epidemiology
C-Reactive Protein / analysis*,  physiology*
Child, Preschool
Hypercholesterolemia / blood*
Pregnancy Complications / blood*
Smoking / adverse effects*
Grant Support
Reg. No./Substance:
9007-41-4/C-Reactive Protein
Comment In:
Am J Obstet Gynecol. 2009 Aug;201(2):e14; author reply e14-5   [PMID:  19306970 ]
Am J Obstet Gynecol. 2009 Jan;200(1):e20-1; author reply e21-2   [PMID:  18845295 ]

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