Document Detail


Maternal BMI, glucose tolerance, and adverse pregnancy outcomes.
MedLine Citation:
PMID:  22609018     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The purpose of this study was to estimate the association of pregravid body mass index (BMI), independent of 3-hour oral glucose tolerance test (OGTT) results, with pregnancy outcome.
STUDY DESIGN: In this secondary analysis of a cohort of women with untreated mild gestational glucose intolerance, which was defined as a 50-g glucose loading test between 135 and 199 mg/dL and fasting glucose level of <95 mg/dL, we modeled the association between pregravid BMI, OGTT results, and both pregnancy complications and neonatal adiposity.
RESULTS: Among 1250 participants, both pregravid BMI and glucose at hour 3 of the OGTT were associated with increased risk of gestational hypertension. Maternal pregravid BMI also was associated positively with large-for-gestational-age infants; both maternal BMI and fasting glucose were associated with birthweight z-score and neonatal fat mass.
CONCLUSION: Among women with untreated mild gestational glucose intolerance, pregravid BMI is associated with increased gestational hypertension, birthweight, and neonatal fat mass, independent of OGTT values.
Authors:
Alison M Stuebe; Mark B Landon; Yinglei Lai; Catherine Y Spong; Marshall W Carpenter; Susan M Ramin; Brian Casey; Ronald J Wapner; Michael W Varner; Dwight J Rouse; Anthony Sciscione; Patrick Catalano; Margaret Harper; George Saade; Yoram Sorokin; Alan M Peaceman; Jorge E Tolosa;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-05-02
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  207     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-25     Completed Date:  2012-08-27     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  62.e1-7     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 Mosby, Inc. All rights reserved.
Affiliation:
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology at University of North Carolina School of Medicine, Chapel Hill, NC 27599-7516, USA. astuebe@med.unc.edu
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MeSH Terms
Descriptor/Qualifier:
Adiposity
Adult
Body Mass Index*
Cohort Studies
Female
Fetal Macrosomia / etiology*
Glucose Intolerance / complications*
Glucose Tolerance Test
Humans
Hypertension, Pregnancy-Induced / etiology*
Infant, Newborn
Linear Models
Logistic Models
Obesity / complications*
Pregnancy
Grant Support
ID/Acronym/Agency:
5K12HD050113-04/HD/NICHD NIH HHS; C06-RR11234/RR/NCRR NIH HHS; HD21410/HD/NICHD NIH HHS; HD27860/HD/NICHD NIH HHS; HD27869/HD/NICHD NIH HHS; HD27915/HD/NICHD NIH HHS; HD27917/HD/NICHD NIH HHS; HD34116/HD/NICHD NIH HHS; HD34136/HD/NICHD NIH HHS; HD34208/HD/NICHD NIH HHS; HD36801/HD/NICHD NIH HHS; HD40485/HD/NICHD NIH HHS; HD40500/HD/NICHD NIH HHS; HD40512/HD/NICHD NIH HHS; HD40544/HD/NICHD NIH HHS; HD40545/HD/NICHD NIH HHS; HD40560/HD/NICHD NIH HHS; HD53097/HD/NICHD NIH HHS; HD53118/HD/NICHD NIH HHS; M01-RR00034/RR/NCRR NIH HHS; M01-RR00080/RR/NCRR NIH HHS; U10 HD027915/HD/NICHD NIH HHS; UL1 RR024989/RR/NCRR NIH HHS; UL1-RR024989/RR/NCRR NIH HHS; UL1-RR025764/RR/NCRR NIH HHS
Investigator
Investigator/Affiliation:
J Thorp / ; K Dorman / ; S Brody / ; S Timlin / ; J Bernhardt / ; K Leveno / ; L Moseley / ; J Gold / ; D Bradford / ; L Fay / ; M Garcia / ; F Capellan / ; M Miodovnik / ; F Malone / ; S Bousleiman / ; H Husami / ; V Carmona / ; N Fredericks / ; E Gantioqui / ; B Greenspan / ; M Williams / ; K Anderson / ; P Ashby / ; S McAllister / ; S Quinn / ; A Guzman / ; F Castinella / ; J Steiner / ; J Parker / ; J Sheppard / ; J Tisdale / ; A Northen / ; W Andrews / ; D Catlow / ; D Allard / ; M Seebeck / ; J Tillinghast / ; J Iams / ; F Johnson / ; C Latimer / ; E Weinandy / ; B Maselli / ; M Hoffman / ; E Guzman / ; M Talucci / ; T Grossman / ; C Perez / ; L Zeghibe / ; P Tabangin / ; B Mercer / ; B Stetzer / ; C Milluzzi / ; W Dalton / ; S Pichette / ; M Swain / ; P Meis / ; J White / ; L Gilstrap / ; K Cannon / ; J Martinez / ; D Dusek / ; J Moss / ; J Brandon / ; A Jackson / ; G Hankins / ; D Sharp / ; S Caritis / ; M Bickus / ; H Birkland / ; M Cotroneo / ; N Cuddy / ; G Norman / ; P Lockhart / ; S Blackwell / ; L Quast / ; P Simon / ; G Mallett / ; L Davis / ; E Lairson / ; C Cromett / ; C Naze / ; M Blaser / ; E Thom / ; L Mele / ; J Zachary / ; B Getachew / ; C Cobb / ; L Leuchtenburg / ; S Gilbert / ; S Tolivaisa / ; K Howell / ; G D Anderson /
Comments/Corrections

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