Document Detail

Maternal B vitamin status in pregnancy week 18 according to reported use of folic acid supplements.
MedLine Citation:
PMID:  23001761     Owner:  NLM     Status:  MEDLINE    
SCOPE: Epidemiological studies on the association between pregnancy outcomes and use of periconceptional folic acid are often based on maternal reported intake. Use of folic acid during pregnancy is associated with a higher socioeconomic status known to have an impact on diet quality. We have studied plasma B vitamin status according to reported use of folic acid supplements during the periconceptional period in Norwegian women.
METHODS AND RESULTS: Plasma levels of folate, cobalamin, pyridoxal 5'-phosphate (vitamin B6), riboflavin, and the metabolic markers total homocysteine, methylmalonic acid and 3-hydro-xykynurenine were measured in pregnancy week 18 and related to reported intake of folic acid from 4 weeks prior to conception throughout week 18 in 2911 women from the Norwegian Mother and Child Cohort Study (MoBa) conducted by the Norwegian Institute of Public Health. Being a folic acid user during the periconceptional period was associated with a better socioeconomic status, and a higher intake of several micronutrients, including vitamins, trace-metals, and omega 3 fatty acids. Folic acid users had a significantly better plasma B vitamin status.
CONCLUSION: Epidemiological data based on maternal reported intake of folic acid supplements during pregnancy, should take into account the numerous nutritional implications, in addition to higher blood folate levels, of being a folic acid user.
Anne Lise Bjørke-Monsen; Christine Roth; Per Magnus; Øivind Midttun; Roy M Nilsen; Ted Reichborn-Kjennerud; Camilla Stoltenberg; Ezra Susser; Stein Emil Vollset; Per Magne Ueland
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-09-24
Journal Detail:
Title:  Molecular nutrition & food research     Volume:  57     ISSN:  1613-4133     ISO Abbreviation:  Mol Nutr Food Res     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-04-04     Completed Date:  2013-10-29     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  101231818     Medline TA:  Mol Nutr Food Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  645-52     Citation Subset:  IM    
Copyright Information:
© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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MeSH Terms
Biological Markers / blood
Dietary Supplements*
Fatty Acids, Omega-3 / administration & dosage
Folic Acid / administration & dosage*,  blood
Homocysteine / blood
Maternal Nutritional Physiological Phenomena*
Methylmalonic Acid / blood
Micronutrients / administration & dosage
Prospective Studies
Riboflavin / blood
Socioeconomic Factors
Vitamin B 12 / blood
Vitamin B 6 / blood
Vitamin B Complex / administration & dosage*,  blood
Grant Support
1 U01 NS 047537-01/NS/NINDS NIH HHS; AS6247//Autism Speaks; N0-ES-75558/ES/NIEHS NIH HHS; U01 NS047537/NS/NINDS NIH HHS
Reg. No./Substance:
0/Biological Markers; 0/Fatty Acids, Omega-3; 0/Micronutrients; 0LVT1QZ0BA/Homocysteine; 12001-76-2/Vitamin B Complex; 8059-24-3/Vitamin B 6; 8LL8S712J7/Methylmalonic Acid; 935E97BOY8/Folic Acid; P6YC3EG204/Vitamin B 12; TLM2976OFR/Riboflavin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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