Document Detail


Maternal Alcohol Use during Pregnancy, Birth Weight and Early Behavioral Outcomes.
MedLine Citation:
PMID:  22893227     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AIMS: To examine the effect of maternal alcohol use during pregnancy on infant behavioral outcomes and birth weight, and to investigate the differential susceptibility of infant behavioral outcomes and birth weight to prenatal alcohol exposure. METHODS: Data on children born to women taking part in the United States National Longitudinal Survey of Youth (NLSY) (n = 1618) were analyzed using the sibling fixed-effects model, which helps adjust for maternal, genetic and social confounders when examining effects of pre-natal exposure to possible toxins such as alcohol. Mothers were classified as non-drinkers, light-to-moderate drinkers and heavy drinkers according to their frequency of alcohol use during pregnancy. Infants' behavioral outcomes were assessed using the modified Rothbart Infant Behavior Questionnaire in the NLSY, which measures three dimensions of behavioral outcomes: positive mood, fearfulness and difficultness. RESULTS: Estimates from the model indicated that drinking during pregnancy was positively associated with infant difficultness, but not with positive mood or fearfulness. Further analysis by frequency of alcohol use suggested that both light-to-moderate and heavy drinking were associated with an increase in infant difficultness. Additionally, while low-to-moderate drinking during pregnancy was associated with infant difficultness, drinking at this level was not associated with low birth weight. CONCLUSION: The findings suggest that maternal alcohol use during pregnancy is a risk factor for infant behavioral outcomes, after taking into account many confounding factors. Infant behavioral outcomes appear to be more vulnerable to light-to-moderate levels of alcohol use during pregnancy than birth weight is.
Authors:
Jen-Hao Chen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-14
Journal Detail:
Title:  Alcohol and alcoholism (Oxford, Oxfordshire)     Volume:  -     ISSN:  1464-3502     ISO Abbreviation:  Alcohol Alcohol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8310684     Medline TA:  Alcohol Alcohol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
University of Chicago, 1155 East 60th Street, Chicago, IL 60637, USA.
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