Document Detail


Maternal alcohol use during pregnancy causes systemic oxidation of the glutathione redox system.
MedLine Citation:
PMID:  19860801     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Increased systemic oxidant stress contributes to a variety of maternal complications of pregnancy. Although the antioxidant glutathione (GSH) and its oxidized component glutathione disulfide (GSSG) have been demonstrated to be significantly altered in the adult alcoholic, the effects of maternal alcohol use during pregnancy on oxidant stress in the postpartum female remain under investigation. We hypothesized that maternal alcohol use would increase systemic oxidant stress in the pregnant female, evidenced by an oxidized systemic GSH redox potential.
METHODS: As a subset analysis of a larger maternal language study, we evaluated the effects of alcohol consumption during pregnancy on the systemic GSH redox status of the postpartum female. Using an extensive maternal questionnaire, postpartum women where queried regarding their alcohol consumption during pregnancy. Any drinking, the occurrence of drinking >3 drinks/occasion, and heavy drinking of >5 drinks/occasion during pregnancy were noted. Using HPLC, maternal plasma samples were analyzed for GSH, oxidized GSSG and the redox potential of the GSH/GSSG antioxidant pair calculated.
RESULTS: Maternal alcohol use occurred in 25% (83/321) of our study sample. Two in ten women reported consuming >3 drinks/occasion during pregnancy, while 1 in 10 women reported consuming alcohol at >5 drinks/occasion. Any alcohol use during pregnancy significantly decreased plasma GSH (p < 0.05), while alcohol at >3 drinks/occasion or >5 drinks/occasion significantly decreased plasma GSH concentration (p < 0.05), increased the percent of oxidized GSSG (p < 0.05), and substantially oxidized the plasma GSH redox potential (p < 0.05).
CONCLUSIONS: Alcohol use during pregnancy, particularly at levels >3 drinks/occasion, caused significant oxidation of the systemic GSH system in the postpartum women. The clinical ramifications of the observed alcohol-induced oxidation of the GSH redox system on high risk pregnancies or on the exposed offspring require more accurate identification and further investigation.
Authors:
Theresa W Gauthier; Julie A Kable; Leandrea Burwell; Claire D Coles; Lou Ann S Brown
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2009-10-23
Journal Detail:
Title:  Alcoholism, clinical and experimental research     Volume:  34     ISSN:  1530-0277     ISO Abbreviation:  Alcohol. Clin. Exp. Res.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-18     Completed Date:  2010-08-10     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  7707242     Medline TA:  Alcohol Clin Exp Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  123-30     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Alcohol Drinking / blood,  metabolism*
Cohort Studies
Female
Glutathione / blood,  metabolism*
Humans
Infant, Newborn
Longitudinal Studies
Maternal Exposure / adverse effects*
Oxidation-Reduction
Oxidative Stress / physiology*
Pregnancy
Young Adult
Grant Support
ID/Acronym/Agency:
P50 AA 135757/AA/NIAAA NIH HHS; P50 AA013757/AA/NIAAA NIH HHS; P50 AA013757-059001/AA/NIAAA NIH HHS; P50 AA013757-06A15994/AA/NIAAA NIH HHS; P50 AA013757-06A15996/AA/NIAAA NIH HHS; R01 HD041203/HD/NICHD NIH HHS; R01 HD041203-01A2/HD/NICHD NIH HHS; R01 HD041203-01A2/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
GAN16C9B8O/Glutathione
Comments/Corrections

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