Document Detail


Maternal alcohol consumption, alcohol metabolism genes, and the risk of oral clefts: a population-based case-control study in Norway, 1996-2001.
MedLine Citation:
PMID:  20810466     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Heavy maternal alcohol consumption during early pregnancy increases the risk of oral clefts, but little is known about how genetic variation in alcohol metabolism affects this association. Variants in the alcohol dehydrogenase 1C (ADH1C) gene may modify the association between alcohol and clefts. In a population-based case-control study carried out in Norway (1996-2001), the authors examined the association between maternal alcohol consumption and risk of oral clefts according to mother and infant ADH1C haplotypes encoding fast or slow alcohol-metabolizing phenotypes. Subjects were 483 infants with oral cleft malformations and 503 control infants and their mothers, randomly selected from all other livebirths taking place during the same period. Mothers who consumed 5 or more alcoholic drinks per sitting during the first trimester of pregnancy had an elevated risk of oral cleft in their offspring (odds ratio (OR) = 2.6, 95% confidence interval (CI): 1.4, 4.7). This increased risk was evident only in mothers or children who carried the ADH1C haplotype associated with reduced alcohol metabolism (OR= 3.0, 95% CI: 1.4, 6.8). There was no evidence of alcohol-related risk when both mother and infant carried only the rapid-metabolism ADH1C variant (OR = 0.9, 95% CI: 0.2, 4.1). The teratogenic effect of alcohol may depend on the genetic capacity of the mother and fetus to metabolize alcohol.
Authors:
Abee L Boyles; Lisa A DeRoo; Rolv T Lie; Jack A Taylor; Astanand Jugessur; Jeffrey C Murray; Allen J Wilcox
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't     Date:  2010-09-01
Journal Detail:
Title:  American journal of epidemiology     Volume:  172     ISSN:  1476-6256     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-11     Completed Date:  2010-11-02     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  924-31     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Alcohol Dehydrogenase / genetics*
Alcohol Drinking / genetics*,  metabolism*
Case-Control Studies
Cleft Palate / chemically induced*,  genetics*
Ethanol / metabolism*,  toxicity
Female
Haplotypes
Humans
Norway / epidemiology
Polymorphism, Single Nucleotide
Pregnancy
Pregnancy Trimester, First
Prenatal Exposure Delayed Effects / genetics*
Socioeconomic Factors
Grant Support
ID/Acronym/Agency:
DE085592/DE/NIDCR NIH HHS; N01-HG-65403/HG/NHGRI NIH HHS; R01 DE-11948-04/DE/NIDCR NIH HHS; R37 DE008559/DE/NIDCR NIH HHS; Z01 ES040007/ES/NIEHS NIH HHS; Z01 ES049027-11/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
3K9958V90M/Ethanol; EC 1.1.1.1/ADH1C protein, human; EC 1.1.1.1/Alcohol Dehydrogenase
Comments/Corrections

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