Document Detail


Maternal aerobic exercise during pregnancy can increase spatial learning by affecting leptin expression on offspring's early and late period in life depending on gender.
MedLine Citation:
PMID:  23028249     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Maternal exercise during pregnancy has been suggested to exert beneficial effects on brain functions of the offspring. Leptin is an adipocytokine which is secreted from adipose tissues and has positive effects on learning, memory, and synaptic plasticity. In this study, pregnant rats were moderately exercised and we observed the effects of this aerobic exercise on their prepubertal and adult offsprings' spatial learning, hippocampal neurogenesis, and expression of leptin. All the pups whose mothers exercised during pregnancy learned the platform earlier and spent longer time in the target quadrant. Their thigmotaxis times were shorter than those measured in the control group. It is shown that hippocampal CA1, CA3 neuron numbers increased in both prepubertal and adult pups, in addition that GD neuron numbers increased in adult pups. Leptin receptor expression significantly increased in the prepubertal male, adult male, and adult female pups. In our study, maternal running during pregnancy resulted in significant increase in the expression of leptin receptor but not in prepubertal female pups, enhanced hippocampal cell survival, and improved learning memory capability in prepubertal and adult rat pups, as compared to the control group. In conclusion, maternal exercise during pregnancy may regulate spatial plasticity in the hippocampus of the offspring by increasing the expression of leptin.
Authors:
Ayfer Dayi; Sinem Agilkaya; Seda Ozbal; Ferihan Cetin; Ilkay Aksu; Celal Gencoglu; Sultan Cingoz; Cetın Pekcetin; Kazim Tugyan; Berkant Muammer Kayatekin; Nazan Uysal
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Publication Detail:
Type:  Journal Article     Date:  2012-09-16
Journal Detail:
Title:  TheScientificWorldJournal     Volume:  2012     ISSN:  1537-744X     ISO Abbreviation:  ScientificWorldJournal     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-02     Completed Date:  2013-02-21     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101131163     Medline TA:  ScientificWorldJournal     Country:  England    
Other Details:
Languages:  eng     Pagination:  429803     Citation Subset:  IM    
Affiliation:
Department of Physiology, School of Medicine, Dokuz Eylul University, 35340 Izmir, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Animals
CA1 Region, Hippocampal / physiology
CA3 Region, Hippocampal / physiology
Cell Survival
Dentate Gyrus / physiology
Female
Male
Maze Learning / physiology*
Memory / physiology
Neurogenesis
Neuronal Plasticity / physiology
Neurons / physiology
Physical Conditioning, Animal / physiology*
Pregnancy
Rats
Rats, Wistar
Receptors, Leptin / physiology*
Sex Factors
Statistics, Nonparametric
Chemical
Reg. No./Substance:
0/Receptors, Leptin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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