Document Detail


Matching dicrotic notch and mean pulmonary artery pressures: implications for effective arterial elastance.
MedLine Citation:
PMID:  8897919     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has been suggested that pulmonary artery pressure at the end of ejection is close to mean pulmonary artery pressure, thus contributing to the optimization of external power from the right ventricle. We tested the hypothesis that dicrotic notch and mean pulmonary artery pressures could be of similar magnitude in 15 men (50 +/- 12 yr) referred to our laboratory for diagnostic right and left heart catheterization. Beat-to-beat relationships between dicrotic notch and mean pulmonary artery pressures were studied 1) at rest over 10 consecutive beats and 2) in 5 patients during the Valsalva maneuver (178 beats studied). At rest, there was no difference between dicrotic notch and mean pulmonary artery pressures (21.8 +/- 12.0 vs. 21.9 +/- 11.1 mmHg). There was a strong linear relationship between dicrotic notch and mean pressures 1) over the 10 consecutive beats studied in each patient (mean r = 0.93), 2) over the 150 resting beats (r = 0.99), and 3) during the Valsalva maneuver in each patient (r = 0.98-0.99) and in the overall beats (r = 0.99). The difference between dicrotic notch and mean pressures was -0.1 +/- 1.7 mmHg at rest and -1.5 +/- 2.3 mmHg during the Valsalva maneuver. Substitution of the mean pulmonary artery pressure by the dicrotic notch pressure in the standard formula of the pulmonary vascular resistance (PVR) resulted in an equation relating linearly end-systolic pressure and stroke volume. The slope of this relation had the dimension of a volume elastance (in mmHg/ml), a simple estimate of volume elastance being obtained as 1.06(PVR/T), where T is duration of the cardiac cycle. In conclusion, dicrotic notch pressure was of similar magnitude as mean pulmonary artery pressure. These results confirmed our primary hypothesis and indicated that human pulmonary artery can be treated as if it is an elastic chamber with a volume elastance of 1.06(PVR/T).
Authors:
D Chemla; J L Hébert; C Coirault; S Salmeron; K Zamani; Y Lecarpentier
Related Documents :
20225909 - Phosphodiesterase type 5 inhibitors for high-altitude pulmonary hypertension: a meta-an...
8914879 - Doppler estimation of pulmonary artery end-diastolic pressure using contrast enhancemen...
10022599 - Nebulization of sodium nitroprusside in lung-lavaged newborn piglets.
6491069 - Noninvasive estimation of peak pulmonary artery pressure by m-mode echocardiography.
18800959 - Intravenous tezosentan and vardenafil attenuate acute hypoxic pulmonary hypertension.
3867069 - Specific hemodynamic effects of pge2 and pgf1 alpha in the canine lung.
6617679 - Survival following massive overdose of adrenergic blocking agents (acebutolol and labet...
9486289 - Influences of melatonin administration on the circulation of women.
3496779 - Effects on hemodynamics and left ventricular ejection fraction of intravenous bepridil ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  271     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1996-12-16     Completed Date:  1996-12-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H1287-95     Citation Subset:  IM    
Affiliation:
Institut National de la Santé et de la Recherche Médicale U. 451, Loa-Ensta-Ecole Polytechnique, Palaiseau, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Blood Pressure*
Cardiovascular Diseases / physiopathology
Elasticity
Humans
Male
Middle Aged
Pulmonary Artery / physiopathology*
Rest
Stroke Volume
Systole
Valsalva Maneuver

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Temporal and spatial relationship between no-reflow phenomenon and postischemic necrosis in skeletal...
Next Document:  L-arginine augments nitric oxide production and mesenteric blood flow in ovine endotoxemia.