Document Detail


Mastocytoma-induced suppression of in vitro antibody formation.
MedLine Citation:
PMID:  805435     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mastocytoma cells in vitro suppressed the immune response of normal syngeneic spleen cells to sheep erythrocytes. The immune response of dispersed spleen cells from normal mice in vitro was inhibited by simultaneous incubation with relatively small numbers of mastocytoma cells or a cell-free extract prepared from these cells. Inhibition occurred when diluted cell-free extracts from the mastocytoma cells or as few as 10-4 or 10-5 tumor cells were incubated with 5 million normal splenocytes. The supernatant factor from mastocytoma cells was labile to heating at 56 degrees for 30 min. Detailed examination of the physicochemical properties of the mastocytoma cell extract capable of suppressing immune responses to sheep red cells should be of value.
Authors:
I Kamo; J Kateley; H Freidman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)     Volume:  148     ISSN:  0037-9727     ISO Abbreviation:  Proc. Soc. Exp. Biol. Med.     Publication Date:  1975 Mar 
Date Detail:
Created Date:  1975-07-24     Completed Date:  1975-07-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7505892     Medline TA:  Proc Soc Exp Biol Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  883-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibody Formation*
Antigens, Neoplasm
Antigens, Viral
Cattle
Hemolytic Plaque Technique
Hot Temperature
Immunity, Cellular*
Immunosuppression
Mast-Cell Sarcoma / immunology*,  pathology
Mice
Mice, Inbred DBA
Neoplasm Transplantation
Sarcoma, Experimental / immunology,  pathology
Sheep / immunology
Spleen / cytology,  immunology
Transplantation Immunology
Transplantation, Homologous
Chemical
Reg. No./Substance:
0/Antigens, Neoplasm; 0/Antigens, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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