| Mastocytoma-induced suppression of in vitro antibody formation. | |
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MedLine Citation:
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PMID: 805435 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mastocytoma cells in vitro suppressed the immune response of normal syngeneic spleen cells to sheep erythrocytes. The immune response of dispersed spleen cells from normal mice in vitro was inhibited by simultaneous incubation with relatively small numbers of mastocytoma cells or a cell-free extract prepared from these cells. Inhibition occurred when diluted cell-free extracts from the mastocytoma cells or as few as 10-4 or 10-5 tumor cells were incubated with 5 million normal splenocytes. The supernatant factor from mastocytoma cells was labile to heating at 56 degrees for 30 min. Detailed examination of the physicochemical properties of the mastocytoma cell extract capable of suppressing immune responses to sheep red cells should be of value. |
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Authors:
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I Kamo; J Kateley; H Freidman |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) Volume: 148 ISSN: 0037-9727 ISO Abbreviation: Proc. Soc. Exp. Biol. Med. Publication Date: 1975 Mar |
Date Detail:
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Created Date: 1975-07-24 Completed Date: 1975-07-24 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7505892 Medline TA: Proc Soc Exp Biol Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 883-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibody Formation* Antigens, Neoplasm Antigens, Viral Cattle Hemolytic Plaque Technique Hot Temperature Immunity, Cellular* Immunosuppression Mast-Cell Sarcoma / immunology*, pathology Mice Mice, Inbred DBA Neoplasm Transplantation Sarcoma, Experimental / immunology, pathology Sheep / immunology Spleen / cytology, immunology Transplantation Immunology Transplantation, Homologous |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Neoplasm; 0/Antigens, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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