Document Detail


Master regulators or lineage-specifying? Changing views on CD4+ T cell transcription factors.
MedLine Citation:
PMID:  23059426     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is an emerging body of research demonstrating that the co-expression of key lineage-specifying transcription factors, commonly referred to as 'master regulators', affects the functional capabilities and flexibility of CD4(+) T cell subsets. Here, we discuss how the natural co-expression of these lineage-specifying transcription factors has challenged the concept that the expression of a single 'master regulator' strictly establishes an absolute CD4(+) T cell phenotype. Instead, it is becoming clear that the interplay between the lineage-specifying (or lineage-defining) transcription factors, including T-bet, GATA3, RORγt, BCL-6 and FOXP3, contributes to the fate and flexibility of CD4(+) T cell subtypes. This in turn has led to the realization that CD4(+) T cell phenotypes are more diverse than previously recognized.
Authors:
Kenneth J Oestreich; Amy S Weinmann
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-10-12
Journal Detail:
Title:  Nature reviews. Immunology     Volume:  12     ISSN:  1474-1741     ISO Abbreviation:  Nat. Rev. Immunol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-25     Completed Date:  2013-01-04     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101124169     Medline TA:  Nat Rev Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  799-804     Citation Subset:  IM    
Affiliation:
Department of Immunology, University of Washington, Box 357650, 1959 NE Pacific Street, Seattle, Washington 98195, USA.
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MeSH Terms
Descriptor/Qualifier:
CD4-Positive T-Lymphocytes / immunology*,  metabolism*
Cell Lineage
DNA-Binding Proteins / metabolism
Forkhead Transcription Factors / metabolism
GATA3 Transcription Factor / metabolism
Humans
Nuclear Receptor Subfamily 1, Group F, Member 3 / metabolism
Phenotype
T-Box Domain Proteins / metabolism
Transcription Factors / metabolism*
Grant Support
ID/Acronym/Agency:
AI061061/AI/NIAID NIH HHS; AI07272/AI/NIAID NIH HHS; R01 AI061061/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/BCL6 protein, human; 0/DNA-Binding Proteins; 0/FOXP3 protein, human; 0/Forkhead Transcription Factors; 0/GATA3 Transcription Factor; 0/GATA3 protein, human; 0/Nuclear Receptor Subfamily 1, Group F, Member 3; 0/T-Box Domain Proteins; 0/T-box transcription factor TBX21; 0/Transcription Factors
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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