| Master regulators or lineage-specifying? Changing views on CD4+ T cell transcription factors. | |
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MedLine Citation:
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PMID: 23059426 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is an emerging body of research demonstrating that the co-expression of key lineage-specifying transcription factors, commonly referred to as 'master regulators', affects the functional capabilities and flexibility of CD4(+) T cell subsets. Here, we discuss how the natural co-expression of these lineage-specifying transcription factors has challenged the concept that the expression of a single 'master regulator' strictly establishes an absolute CD4(+) T cell phenotype. Instead, it is becoming clear that the interplay between the lineage-specifying (or lineage-defining) transcription factors, including T-bet, GATA3, RORγt, BCL-6 and FOXP3, contributes to the fate and flexibility of CD4(+) T cell subtypes. This in turn has led to the realization that CD4(+) T cell phenotypes are more diverse than previously recognized. |
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Authors:
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Kenneth J Oestreich; Amy S Weinmann |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-10-12 |
Journal Detail:
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Title: Nature reviews. Immunology Volume: 12 ISSN: 1474-1741 ISO Abbreviation: Nat. Rev. Immunol. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-10-25 Completed Date: 2013-01-04 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 101124169 Medline TA: Nat Rev Immunol Country: England |
Other Details:
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Languages: eng Pagination: 799-804 Citation Subset: IM |
Affiliation:
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Department of Immunology, University of Washington, Box 357650, 1959 NE Pacific Street, Seattle, Washington 98195, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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CD4-Positive T-Lymphocytes
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immunology*,
metabolism* Cell Lineage DNA-Binding Proteins / metabolism Forkhead Transcription Factors / metabolism GATA3 Transcription Factor / metabolism Humans Nuclear Receptor Subfamily 1, Group F, Member 3 / metabolism Phenotype T-Box Domain Proteins / metabolism Transcription Factors / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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AI061061/AI/NIAID NIH HHS; AI07272/AI/NIAID NIH HHS; R01 AI061061/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/BCL6 protein, human; 0/DNA-Binding Proteins; 0/FOXP3 protein, human; 0/Forkhead Transcription Factors; 0/GATA3 Transcription Factor; 0/GATA3 protein, human; 0/Nuclear Receptor Subfamily 1, Group F, Member 3; 0/T-Box Domain Proteins; 0/T-box transcription factor TBX21; 0/Transcription Factors |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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