Document Detail

Mast cells in the synovium and synovial fluid in osteoarthritis.
MedLine Citation:
PMID:  8348268     Owner:  NLM     Status:  MEDLINE    
SF and synovium from normal individuals and patients with OA, RA and traumatic arthritis (TA) were studied for the presence of mast cells (MC). When compared with normals, patients with OA had large numbers of intact and degranulated MC in the synovium and SF of diseased joints. The numbers of MC are comparable with those in RA where they have been implicated in the pathogenesis of joint damage. These data raise the possibility that in OA too MC may participate in the pathological processes in articular and periarticular tissues.
G Dean; J A Hoyland; J Denton; R P Donn; A J Freemont
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of rheumatology     Volume:  32     ISSN:  0263-7103     ISO Abbreviation:  Br. J. Rheumatol.     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-09-13     Completed Date:  1993-09-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8302415     Medline TA:  Br J Rheumatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  671-5     Citation Subset:  AIM; IM    
Department of Rheumatology, and Pathological Sciences, University of Manchester.
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MeSH Terms
Aged, 80 and over
Arthritis / pathology
Arthritis, Rheumatoid / pathology*
Cell Count
Mast Cells / pathology*
Middle Aged
Osteoarthritis / pathology*
Synovial Fluid / cytology*
Synovial Membrane / pathology*

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