Document Detail

Mast cells and histamine: do they influence placental vascular network and development in preeclampsia?
MedLine Citation:
PMID:  22778495     Owner:  NLM     Status:  MEDLINE    
MATERIAL AND METHODS: Placentas from preeclampsia-complicated pregnancies (n = 11) and from physiological pregnancies (n = 11) were acquired after cesarean section. The concentration of histamine was measured, and immunohistochemical staining for mast cell tryptase was performed. Morphometric analysis was then performed.
RESULTS: We noticed significant differences between the examined groups. Notably, in the preeclampsia group compared to the control group, we observed a higher mean histamine concentration, higher mast cell density (MCD), lower mean mast cell (MMCA) and lower vascular/extravascular (V/EVT) index. In physiological pregnancies, a positive correlation was observed between the histamine concentration and V/VEVT index as well as MCD and the V/VEVT index. In contrast, a negative correlation was observed between MMCA and the V/EVT index in physiological pregnancies.
CONCLUSIONS: Based on the data from our study, we suggest that a differential distribution of mast cells and corresponding changes in the concentration of histamine are involved in the defective placental vascularization seen in preeclamptic placentas.
Grzegorz Szewczyk; Michał Pyzlak; Jakub Klimkiewicz; Wacław Smiertka; Magdalena Miedzińska-Maciejewska; Dariusz Szukiewicz
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Publication Detail:
Type:  Journal Article     Date:  2012-06-19
Journal Detail:
Title:  Mediators of inflammation     Volume:  2012     ISSN:  1466-1861     ISO Abbreviation:  Mediators Inflamm.     Publication Date:  2012  
Date Detail:
Created Date:  2012-07-10     Completed Date:  2012-09-26     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  9209001     Medline TA:  Mediators Inflamm     Country:  United States    
Other Details:
Languages:  eng     Pagination:  307189     Citation Subset:  IM    
Department of General and Experimental Pathology, Medical University of Warsaw, Ul. Krakowskie Przedmiescie 26/28, 00-927 Warsaw, Poland.
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MeSH Terms
Histamine / metabolism*
Mast Cells / cytology,  metabolism*
Placenta / metabolism*
Pre-Eclampsia / metabolism*
Pregnancy Complications
Reg. No./Substance:

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