| Mast cells and histamine: do they influence placental vascular network and development in preeclampsia? | |
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MedLine Citation:
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PMID: 22778495 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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MATERIAL AND METHODS: Placentas from preeclampsia-complicated pregnancies (n = 11) and from physiological pregnancies (n = 11) were acquired after cesarean section. The concentration of histamine was measured, and immunohistochemical staining for mast cell tryptase was performed. Morphometric analysis was then performed. RESULTS: We noticed significant differences between the examined groups. Notably, in the preeclampsia group compared to the control group, we observed a higher mean histamine concentration, higher mast cell density (MCD), lower mean mast cell (MMCA) and lower vascular/extravascular (V/EVT) index. In physiological pregnancies, a positive correlation was observed between the histamine concentration and V/VEVT index as well as MCD and the V/VEVT index. In contrast, a negative correlation was observed between MMCA and the V/EVT index in physiological pregnancies. CONCLUSIONS: Based on the data from our study, we suggest that a differential distribution of mast cells and corresponding changes in the concentration of histamine are involved in the defective placental vascularization seen in preeclamptic placentas. |
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Authors:
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Grzegorz Szewczyk; Michał Pyzlak; Jakub Klimkiewicz; Wacław Smiertka; Magdalena Miedzińska-Maciejewska; Dariusz Szukiewicz |
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Publication Detail:
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Type: Journal Article Date: 2012-06-19 |
Journal Detail:
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Title: Mediators of inflammation Volume: 2012 ISSN: 1466-1861 ISO Abbreviation: Mediators Inflamm. Publication Date: 2012 |
Date Detail:
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Created Date: 2012-07-10 Completed Date: 2012-09-26 Revised Date: 2013-03-01 |
Medline Journal Info:
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Nlm Unique ID: 9209001 Medline TA: Mediators Inflamm Country: United States |
Other Details:
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Languages: eng Pagination: 307189 Citation Subset: IM |
Affiliation:
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Department of General and Experimental Pathology, Medical University of Warsaw, Ul. Krakowskie Przedmiescie 26/28, 00-927 Warsaw, Poland. gszew@mp.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Histamine / metabolism* Humans Immunohistochemistry Mast Cells / cytology, metabolism* Placenta / metabolism* Pre-Eclampsia / metabolism* Pregnancy Pregnancy Complications |
| Chemical | |
Reg. No./Substance:
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51-45-6/Histamine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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