Document Detail


Mast cells determine the magnitude of bacterial toxin-induced skin inflammation.
MedLine Citation:
PMID:  18643847     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mast cells are known to be important effector cells in innate immune responses to bacterial infections. However, up to now, neither the mechanisms nor the relevance of mast cell degranulation in innate skin immune responses to bacteria have been adequately addressed. In this article, we show that the bacterial toxins streptolysin O (SLO) and alpha-toxin potently induce degranulation of mast cells in vitro and in vivo. Furthermore, intradermal injection of the toxins results in pronounced skin inflammation, which either resolves quickly within a few h (SLO-induced inflammation) or presents a chronic process with ongoing inflammation for weeks (alpha-toxin). Interestingly, mast cells mediated the inflammatory effects of SLO, but in contrast limited inflammatory skin responses to alpha-toxin. These findings further support the hypothesis that mast cells are critically involved in initiating and modulating optimal host responses to bacteria by either inflammatory or anti-inflammatory effects, depending on the course of the host reaction induced by the pathogen.
Authors:
Martin Metz; Markus Magerl; Nele F Kühl; Angela Valeva; Sucharit Bhakdi; Marcus Maurer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-07-17
Journal Detail:
Title:  Experimental dermatology     Volume:  18     ISSN:  1600-0625     ISO Abbreviation:  Exp. Dermatol.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-16     Completed Date:  2009-04-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9301549     Medline TA:  Exp Dermatol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  160-6     Citation Subset:  IM    
Affiliation:
Department of Dermatology and Allergy, Allergie-Centrum-Charité, Charité-Universitätsmedizin Berlin, Berlin, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bacterial Proteins / administration & dosage,  adverse effects,  pharmacology
Bacterial Toxins / administration & dosage,  adverse effects*,  pharmacology
Dermatitis / microbiology*,  pathology*
Disease Models, Animal
Hemolysin Proteins / administration & dosage,  adverse effects*,  pharmacology
Immune System / physiology
Injections, Intradermal
Mast Cells / drug effects,  pathology*
Mice
Mice, Inbred C57BL
Mice, Mutant Strains
Peritoneum / pathology
Severity of Illness Index
Staphylococcal Infections / immunology,  pathology
Staphylococcus aureus*
Streptococcal Infections / immunology,  pathology
Streptococcus pyogenes*
Streptolysins / administration & dosage,  adverse effects*,  pharmacology
Chemical
Reg. No./Substance:
0/Bacterial Proteins; 0/Bacterial Toxins; 0/Hemolysin Proteins; 0/Streptolysins; 0/staphylococcal alpha-toxin; 0/streptolysin O

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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