| Mast cell regulation via paired immunoglobulin-like receptor PIR-B. | |
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MedLine Citation:
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PMID: 12403357 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Activating (PIR-A) and inhibitory (PIR-B) isoforms of the paired immunoglobulin (Ig)-like receptor family have been evaluated for their modulating potential in mast cell responses to IgE antibody and mast/stem cell growth factor (SCF). Mast cells produce PIR-A and PIR-B, but PIR-B was found to be predominantly expressed on the cell surface, where it was constitutively tyrosine phosphorylated and associated with SHP-1 tyrosine phosphatase. Efficient coligation of PIR-B with FcepsilonRI inhibited IgE-induced mast cell activation and serotonin release. PIR-B and c-kit (or mast/SCF receptor) coligation also inhibited SCF-induced mast cell responses. The PIR-B inhibitory activity was unimpaired in SHP-1-deficient mast cells, perhaps because of non-SHP-1-binding tyrosine-based inhibitory motif in the cytoplasmic tail of PIR-B. This analysis suggests that PIR-B may serve to control mast cell activity. |
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Authors:
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Ching-Cheng Chen; Dong-Won Kong; Max D Cooper; Hiromi Kubagawa |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Immunologic research Volume: 26 ISSN: 0257-277X ISO Abbreviation: Immunol. Res. Publication Date: 2002 |
Date Detail:
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Created Date: 2002-10-29 Completed Date: 2003-04-25 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8611087 Medline TA: Immunol Res Country: United States |
Other Details:
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Languages: eng Pagination: 191-7 Citation Subset: IM |
Affiliation:
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Department of Microbiology, University of Alabama at Birmingham, 35294, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Gene Expression Intracellular Signaling Peptides and Proteins Mast Cells / immunology*, metabolism Mice Protein Tyrosine Phosphatase, Non-Receptor Type 6 Protein Tyrosine Phosphatases / metabolism Proto-Oncogene Proteins c-kit / metabolism Rats Receptors, IgE / metabolism Receptors, Immunologic / chemistry, genetics, metabolism* Recombinant Fusion Proteins / chemistry, genetics, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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AI42127/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Intracellular Signaling Peptides and Proteins; 0/Pira1 protein, mouse; 0/Pirb protein, mouse; 0/Pirb protein, rat; 0/Receptors, IgE; 0/Receptors, Immunologic; 0/Recombinant Fusion Proteins; EC 2.7.10.1/Proto-Oncogene Proteins c-kit; EC 3.1.3.48/Protein Tyrosine Phosphatase, Non-Receptor Type 6; EC 3.1.3.48/Protein Tyrosine Phosphatases; EC 3.1.3.48/Ptpn6 protein, mouse; EC 3.1.3.48/Ptpn6 protein, rat |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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