Document Detail


Mast cell population in the frog brain: distribution and influence of thyroid status.
MedLine Citation:
PMID:  20435827     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the developing frog brain, the majority of mast cells (MC) are distributed in the pia mater, and some immature MC are located adjacent to the blood capillaries in and around the neuropil. In the adult brain, MC are more numerous than in pre- and pro-metamorphic tadpoles; they are mainly located within the pia mater and are particularly numerous in the choroid plexuses. Many MC are found within the brain ventricles juxtaposed to the ependymal lining. MC are rarely observed in the brain parenchyma. In the adult brain, MC number is much higher than in the brain of post-metamorphic froglets. In the latter, MC number is nearly 2-fold over that found in the pre-metamorphic brain. Treatment of pre- and pro-metamorphic tadpoles with 3,5,3'-triiodothyronine (T(3)) and thyroxine (T(4)) stimulates overall larval development but does not induce a significant change in MC population within the brain. By contrast, treatment with 6-n-propyl-2-thiouracil (PTU) delays larval development and leads to a significant numerical increase of brain MC. In the adult, PTU treatment also has a similar effect whereas hypophysectomy causes a drastic decrease of MC population. The negative effects of hypophysectomy are successfully counteracted by a two-week replacement therapy with homologous pars distalis homogenate. In the adult frog, MC population seems to be refractory to thyroid hormone treatment. The present study on frog brain suggests that pituitary-thyroid axis may be involved in the regulation of MC frequency.
Authors:
Rossella Monteforte; Claudia Pinelli; Alessandra Santillo; Rakesh K Rastogi; Gianluca Polese; Gabriella Chieffi Baccari
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of experimental biology     Volume:  213     ISSN:  1477-9145     ISO Abbreviation:  J. Exp. Biol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-03     Completed Date:  2010-08-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243705     Medline TA:  J Exp Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1762-70     Citation Subset:  IM    
Affiliation:
Department of Life Sciences, Second University of Naples, Via Vivaldi, 43, 81100 Caserta, Italy.
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MeSH Terms
Descriptor/Qualifier:
Aging / drug effects
Animals
Anura / growth & development,  metabolism*
Brain / anatomy & histology,  cytology*,  drug effects,  growth & development
Hormone Replacement Therapy
Hypophysectomy
Mast Cells / cytology*,  drug effects,  metabolism
Metamorphosis, Biological / drug effects
Paraffin Embedding
Pituitary Gland, Anterior / drug effects
Thiouracil / pharmacology
Thyroid Gland / metabolism*
Thyroxine / pharmacology
Tissue Extracts
Triiodothyronine / pharmacology
Chemical
Reg. No./Substance:
0/Tissue Extracts; 141-90-2/Thiouracil; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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