| Massive splenic infarction in an adolescent with hemoglobin S-HPFH. | |
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MedLine Citation:
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PMID: 23281181 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Hemoglobin sickle-hereditary persistence of fetal hemoglobin (S-HPFH) is a condition in which there is compound heterozygosity for the Hb S mutation and the HPFH deletion. These patients have no anemia, little evidence of hemolysis and generally have a benign clinical course compared to other types of sickle cell anemia. We describe a 19-year-old male with HbS-HPFH who had no history of anemia or vaso-occlusive crisis, who presented with a massive splenic infarct. We conclude that patients with HbS-HPFH can occasionally present with severe complications and require a high level of clinical suspicion for complications when presenting to the hospital. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. |
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Authors:
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Donna Whyte; Bernard Forget; David H K Chui; Hong-Yuan Luo; Farzana Pashankar |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-31 |
Journal Detail:
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Title: Pediatric blood & cancer Volume: - ISSN: 1545-5017 ISO Abbreviation: Pediatr Blood Cancer Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2013-1-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101186624 Medline TA: Pediatr Blood Cancer Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Wiley Periodicals, Inc. |
Affiliation:
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Yale University School of Medicine, New Haven, Connecticut. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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