Document Detail

Massive perivillous fibrinoid causing recurrent placental failure.
MedLine Citation:
PMID:  12628270     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To establish the incidence, recurrence rate and consequences of massive perivillous fibrinoid. DESIGN: Retrospective analysis of the histology of all placentas with a diagnosis of massive perivillous fibrinoid between 1991 and 1998, together with the maternal case records. SETTING: The histopathology department of the Rotunda Hospital, Dublin, Ireland. POPULATION: A relatively homogeneous group of pregnant women in the northern part of Dublin City, which is the catchment area for the Rotunda Hospital, delivered between 1991 and 1998. METHODS: Retrospective review of archival placental pathology and maternal charts. MAIN OUTCOME MEASURES: The incidence of massive perivillous fibrinoid, perinatal outcome and recurrence rate. RESULTS: The incidence of massive perivillous fibrinoid was 0.028%, with a recurrence rate of approximately 18%. All the infants suffered intrauterine growth restriction; there was a 31% fetal loss rate and a 33% preterm delivery rate. CONCLUSIONS: Massive perivillous fibrinoid is associated with intrauterine death, intrauterine growth restriction and preterm delivery. It has a significant recurrence rate and both the clinical findings of intrauterine growth restriction and the postmortem findings imply a syndrome of chronic placental insufficiency.
A L Bane; J E Gillan
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  110     ISSN:  1470-0328     ISO Abbreviation:  BJOG     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-11     Completed Date:  2003-04-28     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  England    
Other Details:
Languages:  eng     Pagination:  292-5     Citation Subset:  AIM; IM    
Department of Histopathology, Rotunda Hospital, Dublin, Ireland.
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MeSH Terms
Abortion, Habitual / etiology,  pathology
Chorionic Villi / pathology*
Fetal Death / etiology,  pathology
Fetal Growth Retardation / etiology,  pathology
Fibrin / metabolism*
Gestational Age
Microscopy, Electron
Obstetric Labor, Premature / etiology,  pathology
Placental Insufficiency / etiology*,  pathology
Retrospective Studies
Reg. No./Substance:

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