| Massive osteolysis of the cervical spine. A case report. | |
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MedLine Citation:
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PMID: 7570181 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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STUDY DESIGN: This study described the course of a case of massive osteolysis (Gorham's disease) of the cervical spine and discussed the literature data. OBJECTIVES: To describe a case of massive osteolysis of the cervical spine with fatal outcome and to discuss the classification of the disease among osteolysis and its therapeutic modalities. SUMMARY OF BACKGROUND DATA: Massive osteolysis is a rare condition (fewer than 100 cases reported in the literature) of unknown etiology, which may involve any bone in the body, with a propensity for the shoulder and pelvic girdle. Few cases of cervical spine involvement were reported. METHODS: The case of a 32-year-old man with fatal progressive massive osteolysis of the cervical spine despite multiple attempts to achieve surgical stabilization was reported. RESULTS: Massive osteolysis was characterized by complete destruction of all or part of a bone by angiomatous tissue and may have represented a local disturbance of osteoclastic activity. No successful therapy was proposed, and the prognosis of spine involvement was very poor. CONCLUSIONS: Massive osteolysis is a rare condition with no successful therapy. The hypothesis of involvement of circulating preosteoclasts in the osteolytic process may suggest treatment attempts with diphosphonates because of the futility of standard bone grafting techniques in spine involvement. |
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Authors:
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H Foult; P Goupille; B Aesch; J P Valat; P Burdin; M Jan |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Spine Volume: 20 ISSN: 0362-2436 ISO Abbreviation: Spine Publication Date: 1995 Jul |
Date Detail:
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Created Date: 1995-11-21 Completed Date: 1995-11-21 Revised Date: 2010-03-24 |
Medline Journal Info:
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Nlm Unique ID: 7610646 Medline TA: Spine (Phila Pa 1976) Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1636-9 Citation Subset: IM |
Affiliation:
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Service de Chirurgie Orthop?dique, CHU, H?pital Trousseau, Tours, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Bone Transplantation Cervical Vertebrae / pathology*, surgery Fatal Outcome Humans Male Osteolysis / radiography, surgery* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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