Document Detail


Massive myocardial calcification in second-trimester fetuses: antenatal detection and causes.
MedLine Citation:
PMID:  15685656     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Massive myocardial calcifications were detected by antenatal ultrasound examination in four second-trimester fetuses. In one fetus, multiple cardiac rhabdomyomas were the initial diagnosis. One fetus presented with arthrogryposis and the brain and spinal cord showed severe hypoxic-ischemic damage. One fetus was hydropic and had severe cardiac malformations. The fourth fetus had congenital heart block and maternal serum was positive for anti-Ro and anti-La antibodies. Myocardial calcifications in the first three fetuses were most likely to be caused by hypoxic-ischemic damage to the heart, and immunological mechanisms were responsible in the other fetus. Antenatally detected myocardial echogenic foci in a fetus leading to a termination of pregnancy or associated with fetal death should be investigated with a full postmortem examination. It is important to confirm the presence of calcifications as distinct from a rhabdomyoma as genetic counseling is completely different. The demonstration of associated lesions in other organs also helps to explain the pathogenesis underlying this condition.
Authors:
Y F Chan; A Sampson
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  25     ISSN:  0960-7692     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-02-07     Completed Date:  2005-06-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  193-6     Citation Subset:  IM    
Copyright Information:
Copyright 2005 ISUOG.
Affiliation:
Department of Anatomical Pathology, Royal Women's Hospital, Melbourne, Australia. yuen.chan@maynegroup.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Calcinosis / etiology,  pathology,  ultrasonography*
Cardiomyopathies / etiology,  pathology,  ultrasonography*
Female
Fetal Diseases / etiology,  pathology,  ultrasonography*
Humans
Pregnancy
Pregnancy Trimester, Second
Ultrasonography, Prenatal / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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