Document Detail

Massive metastatic pulmonary calcification in an infant with aleukemic monocytic leukemia.
MedLine Citation:
PMID:  2423997     Owner:  NLM     Status:  MEDLINE    
An 18-month-old infant with aleukemic monocytic leukemia and osteoclastic bone resorption demonstrated in the pelvis, vertebral bodies, and ribs developed severe refractory hypercalcemia. Bilateral interstitial pulmonary radiopacities developed rapidly, accompanied by hypoxemia and hypercapnea. Von Kossa staining of an open lung biopsy revealed extensive, finely granular metastatic septal calcifications not apparent on H&E-stained sections. Autopsy revealed the massive nature of the pulmonary calcinosis and the presence of additional calcifications in the atrial subendocardium, liver, kidneys, vessels, and skin. Metastatic pulmonary calcification has been infrequently described in infants, and premortem detection of such deposits has been rarely reported. The Von Kossa stain is useful in detecting minute pulmonary calcifications which may radiographically simulate infiltrates of infectious origin.
A D Northcutt; F O Tio; S A Chamblin; H A Britton
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric pathology / affiliated with the International Paediatric Pathology Association     Volume:  4     ISSN:  0277-0938     ISO Abbreviation:  Pediatr Pathol     Publication Date:  1985  
Date Detail:
Created Date:  1986-06-27     Completed Date:  1986-06-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8303527     Medline TA:  Pediatr Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  219-29     Citation Subset:  IM    
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MeSH Terms
Bone Resorption
Calcinosis / etiology*,  pathology
Hypercalcemia / etiology
Leukemia / complications*
Leukemia, Myeloid / complications*
Lung / pathology
Lung Diseases / etiology*,  pathology
Microscopy, Electron
Staining and Labeling

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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