Document Detail


Massive macrophage lipid accumulation presenting as hepatosplenomegaly and lymphadenopathy associated with long-term total parenteral nutrition therapy for short bowel syndrome.
MedLine Citation:
PMID:  9635689     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We present a unique case of massive splenomegaly, hepatomegaly, and lymphadenopathy caused by lipid-laden macrophages in a 50 year old white female with short-bowel syndrome treated with long-term total parenteral nutrition. Using transmission electron microscopy and special stains we were able to show that the total parenteral nutrition lipid component was composed of lipid droplets and micelles morphologically identical to those found in lipid-laden macrophages which had accumulated in the patient's reticuloendothelial system leading to massive splenomegaly, hepatomegaly (without evidence of steatosis) and lymphadenopathy. While this phenomenon has been reported in animal models, no human cases have been previously reported.
Authors:
L A Perez-Jaffe; E E Furth; J M Minda; L D Unger; T J Lawton
Related Documents :
3539299 - Adverse immunologic effects of antithyroid drugs.
1067019 - A cooperative study of sarcoidosis in asia and africa: descriptive epidemiology.
11771799 - Vertebral sarcoidosis of the spine in a football player.
17540509 - Histological diversity of reactive and atypical proliferative lymph node lesions in sys...
8517819 - Pulmonary sarcoidosis and chronic cutaneous atypical mycobacter ulcer.
23252659 - Behçet disease-associated uveitis successfully treated with golimumab.
12953619 - The role of herman hoppe of cincinnati in the initial clinical recognition of myastheni...
10507799 - First report of nonpsychotic self-cannibalism (autophagy), tongue splitting, and scar p...
11819149 - Flexor carpi radialis tendinitis caused by malunited trapezial ridge fracture in a prof...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Human pathology     Volume:  29     ISSN:  0046-8177     ISO Abbreviation:  Hum. Pathol.     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-07-01     Completed Date:  1998-07-01     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9421547     Medline TA:  Hum Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  651-5     Citation Subset:  IM    
Affiliation:
Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia 19104-4283, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Fat Emulsions, Intravenous / adverse effects*
Female
Foam Cells / metabolism,  pathology*
Hepatomegaly / etiology*,  pathology
Humans
Lipid Metabolism
Lymphatic Diseases / etiology*,  pathology
Middle Aged
Parenteral Nutrition / adverse effects*
Short Bowel Syndrome / therapy*
Splenomegaly / etiology*,  pathology
Chemical
Reg. No./Substance:
0/Fat Emulsions, Intravenous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cat-scratch disease simulating Histiocytosis X.
Next Document:  Dose escalation with three-dimensional conformal radiation therapy affects the outcome in prostate c...