Document Detail

Massive macrophage lipid accumulation presenting as hepatosplenomegaly and lymphadenopathy associated with long-term total parenteral nutrition therapy for short bowel syndrome.
MedLine Citation:
PMID:  9635689     Owner:  NLM     Status:  MEDLINE    
We present a unique case of massive splenomegaly, hepatomegaly, and lymphadenopathy caused by lipid-laden macrophages in a 50 year old white female with short-bowel syndrome treated with long-term total parenteral nutrition. Using transmission electron microscopy and special stains we were able to show that the total parenteral nutrition lipid component was composed of lipid droplets and micelles morphologically identical to those found in lipid-laden macrophages which had accumulated in the patient's reticuloendothelial system leading to massive splenomegaly, hepatomegaly (without evidence of steatosis) and lymphadenopathy. While this phenomenon has been reported in animal models, no human cases have been previously reported.
L A Perez-Jaffe; E E Furth; J M Minda; L D Unger; T J Lawton
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Human pathology     Volume:  29     ISSN:  0046-8177     ISO Abbreviation:  Hum. Pathol.     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-07-01     Completed Date:  1998-07-01     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9421547     Medline TA:  Hum Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  651-5     Citation Subset:  IM    
Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia 19104-4283, USA.
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MeSH Terms
Fat Emulsions, Intravenous / adverse effects*
Foam Cells / metabolism,  pathology*
Hepatomegaly / etiology*,  pathology
Lipid Metabolism
Lymphatic Diseases / etiology*,  pathology
Middle Aged
Parenteral Nutrition / adverse effects*
Short Bowel Syndrome / therapy*
Splenomegaly / etiology*,  pathology
Reg. No./Substance:
0/Fat Emulsions, Intravenous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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