| Massive intestinal resection in rats fed up on glutamine: hepatic glycogen content valuation. | |
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MedLine Citation:
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PMID: 16699620 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Glutamine has been widely used in treatment of small bowel syndrome and its metabolic effects on the small intestine are well known, however, it has been little studied its effects on hepatic metabolism under this condition. AIM: To verify through experimental model, a glutamine based supplemental diet, administered via oral to rats submitted to massive intestinal resection, evaluating weight evolution and hepatic glycogen content. MATERIAL AND METHODS: Male rats, Wistar, were allocated into three groups to undergo enterectomy. Following diets were applied: with glutamine (G group), without glutamine (NG group), and standard diet from the laboratory (R group). All animals had massive small intestine resection including ileocecal valve removal. After 20 days, all animals were sacrificed. The liver was removed to histological analysis by light microscopy. Slides were stained by periodic acid of Schiff with diastasis. RESULTS: All animals lost weight from the beginning to the end of experiment. Comparing weight loss average expressed in percentage, there was no difference statistically significant on this variance. In analyzed groups, the hepatic glycogen content did not differ statistically, in the histological method evaluated. CONCLUSION: Glutamine feeding via oral did not influence weight loss reduction of animal submitted to massive intestinal resection and did not stimulate glycogen synthesis and storage into hepatocytes. |
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Authors:
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Ariney Costa de Miranda; Paulo Engler Pinto; Sidney Resende Ribeiro; Samson Henrique Bromberg; Fábio Pinatel Lopasso; Kiyoshi Irya |
Publication Detail:
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Type: Journal Article Date: 2006-05-08 |
Journal Detail:
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Title: Arquivos de gastroenterologia Volume: 43 ISSN: 0004-2803 ISO Abbreviation: Arq Gastroenterol Publication Date: 2006 Jan-Mar |
Date Detail:
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Created Date: 2006-05-15 Completed Date: 2006-08-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 15310600R Medline TA: Arq Gastroenterol Country: Brazil |
Other Details:
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Languages: eng Pagination: 55-8 Citation Subset: IM |
Affiliation:
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Instituto de Assistência ao Servidor Público Estadual, University of São Paulo Medical School, São Paulo, SP, Brazil. ariney_costa@uol.com.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Glutamine / administration & dosage* Hepatocytes / metabolism* Intestine, Small / pathology, surgery* Liver Glycogen / analysis* Male Random Allocation Rats Rats, Wistar Weight Loss |
| Chemical | |
Reg. No./Substance:
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0/Liver Glycogen; 56-85-9/Glutamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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