| Massive feto-maternal haemorrhage: effect of passively administered anti-D in the prevention of Rh sensitization and haemolytic disease of the newborn. | |
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MedLine Citation:
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PMID: 2847774 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fourteen mothers carrying ABO compatible but Rh D incompatible pregnancies experienced large feto-maternal haemorrhages (estimated 188 ml, range 50-400 ml red cells). These were all treated with infusions of fresh frozen plasma containing anti-D at a mean immunoglobulin to fetal cell ratio of 129 i.u. (25.8 micrograms)/ml of fetal cells. At 48 h after the infusion 95% of fetal cells had been removed but 3 to 4 days were required for complete removal. The passively administered anti-D was detectable for up to 6-9 months but not after that time. Four of the 14 women had successful pregnancies subsequently although in two of these anti-C + D was present. Of these, one resulted in a clinically affected baby who survived exchange transfusion. |
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Authors:
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L Mills; J A Napier |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British journal of obstetrics and gynaecology Volume: 95 ISSN: 0306-5456 ISO Abbreviation: Br J Obstet Gynaecol Publication Date: 1988 Oct |
Date Detail:
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Created Date: 1989-01-09 Completed Date: 1989-01-09 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7503752 Medline TA: Br J Obstet Gynaecol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1007-12 Citation Subset: AIM; IM |
Affiliation:
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Welsh Regional Transfusion Centre, Rhydlafar, Cardiff. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Erythroblastosis, Fetal
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prevention & control* Female Fetal Death Fetomaternal Transfusion* Humans Immunization, Passive Immunoglobulins / administration & dosage* Infant, Newborn Pregnancy Rh Isoimmunization / prevention & control* Rho(D) Immune Globulin Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulins; 0/Rho(D) Immune Globulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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