Document Detail

Massive feto-maternal haemorrhage: effect of passively administered anti-D in the prevention of Rh sensitization and haemolytic disease of the newborn.
MedLine Citation:
PMID:  2847774     Owner:  NLM     Status:  MEDLINE    
Fourteen mothers carrying ABO compatible but Rh D incompatible pregnancies experienced large feto-maternal haemorrhages (estimated 188 ml, range 50-400 ml red cells). These were all treated with infusions of fresh frozen plasma containing anti-D at a mean immunoglobulin to fetal cell ratio of 129 i.u. (25.8 micrograms)/ml of fetal cells. At 48 h after the infusion 95% of fetal cells had been removed but 3 to 4 days were required for complete removal. The passively administered anti-D was detectable for up to 6-9 months but not after that time. Four of the 14 women had successful pregnancies subsequently although in two of these anti-C + D was present. Of these, one resulted in a clinically affected baby who survived exchange transfusion.
L Mills; J A Napier
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  95     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1989-01-09     Completed Date:  1989-01-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1007-12     Citation Subset:  AIM; IM    
Welsh Regional Transfusion Centre, Rhydlafar, Cardiff.
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MeSH Terms
Erythroblastosis, Fetal / prevention & control*
Fetal Death
Fetomaternal Transfusion*
Immunization, Passive
Immunoglobulins / administration & dosage*
Infant, Newborn
Rh Isoimmunization / prevention & control*
Rho(D) Immune Globulin
Time Factors
Reg. No./Substance:
0/Immunoglobulins; 0/Rho(D) Immune Globulin

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