Document Detail

Massive antenatal fetomaternal hemorrhage: evidence for long-term survival of fetal red blood cells.
MedLine Citation:
PMID:  15819674     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Massive fetomaternal hemorrhage (FMH) can lead to life-threatening anemia. Quantification based on flow cytometry with anti-hemoglobin F (HbF) is applicable in all cases but underestimation of large fetal bleeds has been reported. A large FMH from an ABO-compatible fetus allows an estimation of the life span of fetal red blood cells (RBCs) in the maternal circulation. CASE REPORT: The mother went to the obstetrician twice antepartum owing to symptoms assumed to be preeclampsia; that, however, was not found. She later delivered by cesarean section owing to diminished fetal movements. No fetal weight gain was observed during the last 2 weeks of pregnancy. STUDY DESIGN AND METHODS: Fetal RBCs were quantified by flow cytometry with anti-HbF, anti-Fy(a), anti-s, and anti-Jk(b) on a regular basis. RESULTS: The infant had anemia at delivery and an FMH was determined to be 314 +/- 17 mL (+/- SD) of whole blood. It is assumed that the two antenatal visits were associated with the FMH. Postpartum follow-up showed that fetal RBCs in the maternal circulation were detectable with anti-HbF up to 119 days. Quantification by flow cytometry based on anti-HbF was in agreement with quantification based on anti-Fy(a), anti-s, and anti-Jk(b), although they were less sensitive. CONCLUSION: ABO-compatible fetal RBCs from an FMH had a life span in the maternal circulation close to that of adult RBCs.
Morten H Dziegiel; Ole Koldkjaer; Adela Berkowicz
Related Documents :
8652484 - Pregnancy in sickle cell disease in the uk: results of a multicentre survey of the effe...
24630464 - Evaluation of postural equilibrium and fall risk during pregnancy.
11764104 - Lethal hydrops fetalis due to congenital dyserythropoietic anemia in a newborn: associa...
20638314 - Should pmm2-deficiency (cdg ia) be searched in every case of unexplained hydrops fetalis?
23563874 - Myasthenia gravis and pregnancy.
18697374 - 50 grams glucose challenge test for screening of gestational diabetes mellitus in each ...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Transfusion     Volume:  45     ISSN:  0041-1132     ISO Abbreviation:  Transfusion     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-11     Completed Date:  2005-05-10     Revised Date:  2006-01-25    
Medline Journal Info:
Nlm Unique ID:  0417360     Medline TA:  Transfusion     Country:  United States    
Other Details:
Languages:  eng     Pagination:  539-44     Citation Subset:  IM    
H:S Blood Bank KI2034, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cell Survival
Erythrocytes / cytology,  immunology
Fetal Blood / immunology*
Fetal Hemoglobin / immunology*
Fetomaternal Transfusion / blood*,  immunology*
Flow Cytometry
Pregnancy Trimester, Third
Time Factors
Reg. No./Substance:
9034-63-3/Fetal Hemoglobin
Comment In:
Transfusion. 2005 Dec;45(12):1985; author reply 1985   [PMID:  16371058 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Presence of RHD in serologically D-, C/E+ individuals: a European multicenter study.
Next Document:  Genetic basis of the K(0) phenotype in the Swedish population.