| Massive antenatal fetomaternal hemorrhage: evidence for long-term survival of fetal red blood cells. | |
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MedLine Citation:
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PMID: 15819674 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Massive fetomaternal hemorrhage (FMH) can lead to life-threatening anemia. Quantification based on flow cytometry with anti-hemoglobin F (HbF) is applicable in all cases but underestimation of large fetal bleeds has been reported. A large FMH from an ABO-compatible fetus allows an estimation of the life span of fetal red blood cells (RBCs) in the maternal circulation. CASE REPORT: The mother went to the obstetrician twice antepartum owing to symptoms assumed to be preeclampsia; that, however, was not found. She later delivered by cesarean section owing to diminished fetal movements. No fetal weight gain was observed during the last 2 weeks of pregnancy. STUDY DESIGN AND METHODS: Fetal RBCs were quantified by flow cytometry with anti-HbF, anti-Fy(a), anti-s, and anti-Jk(b) on a regular basis. RESULTS: The infant had anemia at delivery and an FMH was determined to be 314 +/- 17 mL (+/- SD) of whole blood. It is assumed that the two antenatal visits were associated with the FMH. Postpartum follow-up showed that fetal RBCs in the maternal circulation were detectable with anti-HbF up to 119 days. Quantification by flow cytometry based on anti-HbF was in agreement with quantification based on anti-Fy(a), anti-s, and anti-Jk(b), although they were less sensitive. CONCLUSION: ABO-compatible fetal RBCs from an FMH had a life span in the maternal circulation close to that of adult RBCs. |
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Authors:
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Morten H Dziegiel; Ole Koldkjaer; Adela Berkowicz |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Transfusion Volume: 45 ISSN: 0041-1132 ISO Abbreviation: Transfusion Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-04-11 Completed Date: 2005-05-10 Revised Date: 2006-01-25 |
Medline Journal Info:
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Nlm Unique ID: 0417360 Medline TA: Transfusion Country: United States |
Other Details:
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Languages: eng Pagination: 539-44 Citation Subset: IM |
Affiliation:
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H:S Blood Bank KI2034, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. dzielgiel@rh.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cell Survival Erythrocytes / cytology, immunology Female Fetal Blood / immunology* Fetal Hemoglobin / immunology* Fetomaternal Transfusion / blood*, immunology* Flow Cytometry Humans Pregnancy Pregnancy Trimester, Third Time Factors |
| Chemical | |
Reg. No./Substance:
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9034-63-3/Fetal Hemoglobin |
| Comments/Corrections | |
Comment In:
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Transfusion. 2005 Dec;45(12):1985; author reply 1985
[PMID:
16371058
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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